Results 101 to 110 of about 154,066 (268)

Animal research in the UK: Regulation, implementation, welfare and development of new approach methodologies

Animal Models and Experimental Medicine, EarlyView.
Scientific research with animals in the UK is regulated by the Animals (Scientific Procedures) Act 1986 with the National Centre for the Replacement, Refinement and Reduction of Animals in Research providing support for best practice and facilitating development of new approach methodologies.
Ewan St. John Smith, James Bussell, Maggie Gentry, Elliot Lilley, Cathy Merry, Judy MacArthur Clark, William Reynolds   +6 more
wiley   +1 more source

Qualitative Behavioural Assessment of bonobo emotional expressivity across observer groups and zoo housing environments

Animal Welfare
Human evaluation of animal emotional expressivity can inform animal welfare. Qualitative Behavioural Assessment (QBA) has been applied to domesticated and some non-domesticated animals, but its use in primates is limited despite their emotional ...
Daan W Laméris, Marina Salas, Marcel Eens, Lisa Gillespie, Nicky Staes, Jonas RR Torfs, Jonas Verspeek, Hilde Vervaecke, Samantha J Ward, Jeroen MG Stevens   +9 more
doaj   +1 more source

Dose‐dependent pathogenicity and inflammatory imbalance in severely immunodeficient mice infected with mpox virus

Animal Models and Experimental Medicine, EarlyView.
This study establishes an NPG (NOD.Cg‐Prkdcscid Il2rgtm1/Vst) mouse model for severe monkeypox virus infection in immunocompromised hosts, demonstrating dose‐dependent disease severity and revealing that unbalanced pro‐inflammatory cytokine release drives pathogenesis, providing insights for therapeutic interventions. Abstract The global spread of mpox
Na Li, Ziqing Jia, Zhe Cong, Jianrong Ma, Jiahan Lu, Yongzhi Hou, Fei Wang, Jiasen Yang, Ting Chen, Jingjing Zhang, Dong Zhang, Jing Xue   +11 more
wiley   +1 more source

Monoallelic POLR3A Variants Cause Early‐Onset Peripheral Neuropathy

Annals of Neurology, EarlyView.
Objective Biallelic variants in genes encoding the RNA polymerase III complex (Pol III) cause a spectrum of neurological disorders primarily affecting the central nervous system. Monoallelic variants have been reported in the POLR3B subunit only, associated with neurodevelopmental disorder, epilepsy, and peripheral neuropathy.
Luiza L. P. Ramos, Jevin M. Parmar, Robin Wijngaard, Bianca R. Grosz, Tamas Lazar, Ligia Mateiu, Steve Vucic, Kishore R. Kumar, Dennis Yeow, Laura I. Rudaks, Lonneke de Boer, Annemarie de Vreugd, David A. Koolen, Thatjana Gardeitchik, Anita Cairns, Krishnan Iyengar, Fernando Kok, Fernanda Barbosa Figueiredo, Alzira Alves de Siqueira Carvalho, Luiz S. Mageste Barbosa, Rodrigo Rezende Arantes, Tyler Rehbein, Jordan E. Bontrager, Elizabeth P. Wood, Janet E. Sowden, Gavin Monahan, Meutia Kumaheri, Ivy Cuijt, Melina Ellis, Gonzalo Perez‐Siles, Elyshia McNamara, Ronald van Beek, Celine B. Meijers, Ivaylo Tournev, Stephan Zuchner, Shoshana J. Wodak, Clara D. M. van Karnebeek, Nigel Laing, Liana N. Semcesen, David A. Stroud, David N. Herrmann, Velina Guergueltcheva, Marina L. Kennerson, Machteld M. Oud, Gianina Ravenscroft, Ayse Candayan, Albena Jordanova   +46 more
wiley   +1 more source

Quantitative assessment of masticatory muscles based on skull muscle attachment areas in Carnivora

The Anatomical Record, EarlyView.
Abstract Masticatory muscles are composed of the temporalis, masseter, and pterygoid muscles in mammals. Each muscle has a different origin on the skull and insertion on the mandible; thus, all masticatory muscles contract in different directions. Collecting in vivo data and directly measuring the masticatory muscles anatomically in various Carnivora ...
Kai Ito, Mugino O. Kubo, Ryo Kodera, Sei‐ichiro Takeda, Hideki Endo   +4 more
wiley   +1 more source

Non-human primate model of long-COVID identifies immune associates of hyperglycemia

Nature Communications
Hyperglycemia, and exacerbation of pre-existing deficits in glucose metabolism, are manifestations of the post-acute sequelae of SARS-CoV-2. Our understanding of metabolic decline after acute COVID-19 remains unclear due to the lack of animal models ...
Clovis S. Palmer, Chrysostomos Perdios, Mohamed Abdel-Mohsen, Joseph Mudd, Prasun K. Datta, Nicholas J. Maness, Gabrielle Lehmicke, Nadia Golden, Linh Hellmers, Carol Coyne, Kristyn Moore Green, Cecily Midkiff, Kelsey Williams, Rafael Tiburcio, Marissa Fahlberg, Kyndal Boykin, Carys Kenway, Kasi Russell-Lodrigue, Angela Birnbaum, Rudolf Bohm, Robert Blair, Jason P. Dufour, Tracy Fischer, Ahmad A. Saied, Jay Rappaport   +24 more
doaj   +1 more source

The morphology of the oval window in Paranthropus robustus compared to humans and other modern primates

The Anatomical Record, EarlyView.
Abstract The oval window (OW) is an opening connecting the inner and middle ear. Its area has been shown to consistently scale with body mass (BM) in primates, and has been used alongside semi‐circular canal (SCC) size to differentiate Homo sapiens and fossil hominins, including Paranthropus robustus.
Ruy Fernandez, José Braga
wiley   +1 more source

Histopathological characterization of nephritides in the brown capuchin monkey, Cebus apella (Primates: Cebidae)

Revista de Biología Tropical, 2000
The renal lesions are of special importance in the captive primates. The most commonly pathologies are: pyelonephritis, nephrocalcinosis, glomerulonephritis, congenital malformations, hydronephrosis and functional diseases.
Juan T. Borda, Vanessa Nunes-Bastos, Silvia Pérez-Escalá, Marcial Sánchez-Negrette   +3 more
doaj  

In vitro matured oocytes have a higher developmental potential than in vivo matured oocytes after hormonal ovarian stimulation in Callithrix jacchus

Journal of Ovarian Research
Background The common marmoset, Callithrix jacchus, is an invaluable model in biomedical research. Its use includes genetic engineering applications, which require manipulations of oocytes and production of embryos in vitro.
Olena Y. Tkachenko, Tobias Kahland, Dimitri Lindenwald, Michael Heistermann, Charis Drummer, Maria Daskalaki, Nancy Rüger, Rüdiger Behr   +7 more
doaj   +1 more source

In‐vitro puncture experiment using alligator teeth tracks the formation of dental microwear and its association with hardness of the diet

The Anatomical Record, EarlyView.
Abstract With the development of dental microwear texture analysis (DMTA), there has been an increasing application of DMTA for dietary estimation in extant and fossil reptiles, including dinosaurs. While numerous feeding experiments exist for herbivorous mammals, knowledge remains limited for carnivorous reptiles. This study aimed to qualitatively and
K. Usami, M. O. Kubo
wiley   +1 more source