Results 21 to 30 of about 150,567 (245)

ENVIRONMENTAL STRESS ON THE REPRODUCTION OF NON-HUMAN PRIMATES

Biotropia: The Southeast Asian Journal of Tropical Biology, 2021
The aim of this review paper is to present some aspects of environmental stress, such as climate change and food limitation that could affect nonhuman primate population due to poor reproductive performance.
Mashitah Shikh ShikhMaidin
doaj   +1 more source

Generation and functional characterization of tuft cells in non-human primate pancreatic ducts through organoid culture systems

Frontiers in Cell and Developmental Biology
The pancreatic duct plays a key role in collecting pancreatic juice, which is rich in digestive enzymes. The fluid flows unidirectionally into the duodenum, where it mixes with partially digested food to further facilitate digestion.
Kosuke Sakaguchi, Chiemi Kimura-Nakajima, Akihiko Inaba, Yoshiko Hatano, Hanako Ogawa, Yuichi Koshiishi, Keisuke Tanaka, Tatsuya Kometani, Makoto Ohmoto, Koji Sato, Hiroo Imai, Ken Iwatsuki   +11 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Non-human primate model of long-COVID identifies immune associates of hyperglycemia

Nature Communications
Hyperglycemia, and exacerbation of pre-existing deficits in glucose metabolism, are manifestations of the post-acute sequelae of SARS-CoV-2. Our understanding of metabolic decline after acute COVID-19 remains unclear due to the lack of animal models ...
Clovis S. Palmer, Chrysostomos Perdios, Mohamed Abdel-Mohsen, Joseph Mudd, Prasun K. Datta, Nicholas J. Maness, Gabrielle Lehmicke, Nadia Golden, Linh Hellmers, Carol Coyne, Kristyn Moore Green, Cecily Midkiff, Kelsey Williams, Rafael Tiburcio, Marissa Fahlberg, Kyndal Boykin, Carys Kenway, Kasi Russell-Lodrigue, Angela Birnbaum, Rudolf Bohm, Robert Blair, Jason P. Dufour, Tracy Fischer, Ahmad A. Saied, Jay Rappaport   +24 more
doaj   +1 more source

Localization of multiple pleiotropic genes for lipoprotein metabolism in baboons[S]

Journal of Lipid Research, 2009
We employed a novel approach to identify the key loci that harbor genes influencing lipoprotein metabolism in approximately 2,000 pedigreed baboons fed various diets differing in levels of fat and cholesterol.
David L. Rainwater, Laura A. Cox, Jeffrey Rogers, John L. VandeBerg, Michael C. Mahaney   +4 more
doaj   +1 more source

Primate archaeology evolves [PDF]

Nature Ecology & Evolution, 2017
Since its inception, archaeology has traditionally focused exclusively on humans and our direct ancestors. However, recent years have seen archaeological techniques applied to material evidence left behind by non-human animals. Here, we review advances made by the most prominent field investigating past non-human tool use: primate archaeology.
Haslam, M, Hernandez-Aguilar, R, Proffitt, T, Arroyo, A, Falótico, T, Fragaszy, D, Gumert, M, Harris, J, Huffman, M, Kalan, A, Malaivijitnond, S, Matsuzawa, T, McGrew, W, Ottoni, E, Pascual-Garrido, A, Piel, A, Pruetz, J, Schuppli, C, Stewart, F, Tan, A, Visalberghi, E, Luncz, L   +21 more
openaire   +6 more sources

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source

In vitro matured oocytes have a higher developmental potential than in vivo matured oocytes after hormonal ovarian stimulation in Callithrix jacchus

Journal of Ovarian Research
Background The common marmoset, Callithrix jacchus, is an invaluable model in biomedical research. Its use includes genetic engineering applications, which require manipulations of oocytes and production of embryos in vitro.
Olena Y. Tkachenko, Tobias Kahland, Dimitri Lindenwald, Michael Heistermann, Charis Drummer, Maria Daskalaki, Nancy Rüger, Rüdiger Behr   +7 more
doaj   +1 more source

Primates chunk simultaneously-presented memoranda

Frontiers in Behavioral Neuroscience, 2022
Though much research has characterized both the behavior and electrophysiology of spatial memory for single targets in non-human primates, we know much less about how multiple memoranda are handled. Multiple memoranda may interact in the brain, affecting
Charles D. Holmes, Charles D. Holmes, ShiNung Ching, Lawrence H. Snyder, Lawrence H. Snyder   +4 more
doaj   +1 more source