Results 51 to 60 of about 419,120 (338)

Lactoferrin treatment activates acetylcholinesterase, decreasing acetylcholine levels in non‐small cell lung cancer (NSCLC) cell culture supernatants, inhibiting cell survival

FEBS Open Bio, EarlyView.
Representation of the suggested mode of action of lactoferrin (Lf) in nonsmall cell lung cancer (NSCLC) A549 cells. Lf induces activation of caspase‐3 by activating p53 and AChE leading to decreased ACh concentrations. In turn, ACh signaling leads to activation of VEGF and AKT and blocking of caspase‐3.
Stuti Goel, Caroline Wozniak, Aya Sabri, Ben Haddad, Brooke Lopo, Alvaro Cobos, Sarah Sarofim, Jeffrey Guthrie, Deborah Heyl, Hedeel Guy Evans   +9 more
wiley   +1 more source

Analysis of Streptococcus dysgalactiae subspecies equisimilis gene transcripts during experimental primate necrotizing myositis

mBio
Streptococcus dysgalactiae subspecies equisimilis (SDSE) is a gram-positive bacterial pathogen capable of causing various infections in humans. Recently, isolates of SDSE emm type stG62647 have emerged as a cause of severe invasive infections, including ...
Jesus M. Eraso, Randall J. Olsen, S. Wesley Long, Ahmad Faili, Samer Kayal, James M. Musser   +5 more
doaj   +1 more source

Emotion Evaluation and Response Slowing in a Non-Human Primate: New Directions for Cognitive Bias Measures of Animal Emotion?

Behavioral Sciences, 2016
The cognitive bias model of animal welfare assessment is informed by studies with humans demonstrating that the interaction between emotion and cognition can be detected using laboratory tasks.
Emily J. Bethell, Amanda Holmes, Ann MacLarnon, Stuart Semple   +3 more
doaj   +1 more source

Shared and divergent principles of synaptic transmission between cortical excitatory neurons in rodent and human brain

Frontiers in Synaptic Neuroscience, 2023
Information transfer between principal neurons in neocortex occurs through (glutamatergic) synaptic transmission. In this focussed review, we provide a detailed overview on the strength of synaptic neurotransmission between pairs of excitatory neurons in
Christiaan P. J. de Kock, Dirk Feldmeyer, Dirk Feldmeyer, Dirk Feldmeyer   +3 more
doaj   +1 more source

Comparing the cost-effectiveness of methods for estimating population density for primates in the Amazon rainforest Peru [PDF]

, 2015
With increasingly extreme fluctuations in flood levels in the Amazon basin (Malhi et al. 2008, Marengo et al. 2012, Bodmer et al. 2014) the future of its' fauna is becoming more uncertain.
Bowles, Matthew David
core  

Next‐Generation Bio‐Reducible Lipids Enable Enhanced Vaccine Efficacy in Malaria and Primate Models

Advanced Functional Materials, EarlyView.
Structure–activity relationship (SAR) optimization of bio‐reducible ionizable lipids enables the development of highly effective lipid nanoparticle (LNP) mRNA vaccines. Lead LNPs show superior tolerability and antibody responses in rodents and primates, outperforming approved COVID‐19 vaccine lipids.
Ruben De Coen, Sabah Kasmi, Shrinivas Dumbre, Lies Baekens, Elise Seynaeve, Louise Van den Hauwe, Niccolò Cantini, Aello Garantoudi, Filipe Branco Madeira, Alain Marrot, Emma Tuypens, Sofie Seghers, Anna Kuchmiy, Elisabeth Brabants, Bart Vanderborght, Ine Maes, Sarah Vandenberghe, Jessica Filtjens, Alícia Gordún Peiró, Daliya Kancheva, Ayla Debraekeleer, Florence Lambolez, Emily De Lombaerde, Yong Chen, Rafael Miyazawa Martins, Pauline Formaglio, Damya Laoui, Sofie Deschoemaeker, Bruno G. De Geest, Rogerio Amino, Stefaan De Koker   +30 more
wiley   +1 more source

Historical Demography and Species Distribution Models Shed Light on Speciation in Primates of Northeast India

Ecology and Evolution
Past climate change is one of the important factors influencing primate speciation. Populations of various species could have risen or declined in response to these climatic fluctuations.
Mihir Trivedi, Kunal Arekar, Shivakumara Manu, Lukas F. K. Kuderna, Jeffrey Rogers, Kyle Kai‐How Farh, Tomas Marques Bonet, Govindhaswamy Umapathy   +7 more
doaj   +1 more source

Radioimmunoassay of human plasma Lp(a) lipoprotein

Journal of Lipid Research, 1977
A quantitative immunodiffusion assay demonstrated Lp(a) lipoprotein in 91% (911 of 1000) of subjects. In order to quantitate Lp(a) in all plasma, a sensitive and specific double antibody radioimmunoassay was developed.
J J Albers, J L Adolphson, W R Hazzard
doaj   +1 more source

Malaria disrupts the rhesus macaque gut microbiome

Frontiers in Cellular and Infection Microbiology, 2023
Previous studies have suggested that a relationship exists between severity and transmissibility of malaria and variations in the gut microbiome, yet only limited information exists on the temporal dynamics of the gut microbial community during a ...
Danielle N. Farinella, Sukhpreet Kaur, ViLinh Tran, Monica Cabrera-Mora, Monica Cabrera-Mora, Chester J. Joyner, Chester J. Joyner, Stacey A. Lapp, Stacey A. Lapp, Suman B. Pakala, Mustafa V. Nural, Jeremy D. DeBarry, Jeremy D. DeBarry, Jeremy D. DeBarry, Jessica C. Kissinger, Jessica C. Kissinger, Jessica C. Kissinger, Dean P. Jones, Alberto Moreno, Alberto Moreno, Alberto Moreno, Mary R. Galinski, Mary R. Galinski, Mary R. Galinski, Regina Joice Cordy, Regina Joice Cordy   +25 more
doaj   +1 more source

PRELIVE: A Framework for Predicting Lipid Nanoparticles In Vivo Efficacy and Reducing Reliance on Animal Testing

Advanced Functional Materials, EarlyView.
PREdicting LNP In Vivo Efficacy (PRELIVE) framework enables the prediction of lipid nanoparticle (LNPs) organ‐specific delivery through dual modeling approaches. Composition‐based models using formulation parameters and protein corona‐based models using biological fingerprints both achieve high predictive accuracy across multiple organs.
Belal I. Hanafy, Chuan‐En Lu, Kai Liu, Audrey Gallud   +3 more
wiley   +1 more source