Results 111 to 120 of about 2,557,900 (273)

Innovation-systems, path-dependency and policy: The co-evolution of science, technology and innovation policy and industrial structure in a small, resource-based economy [PDF]

This paper analyses the co-evolution of science, technology and innovation policy and industrial structure in a small, resource-based economy (Norway). The contributions of the paper are threefold.
Bart Verspagen, David Mowery, Jan Fagerberg   +2 more
core  

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

BLOCK NUMERICAL INTEGRATOR FOR THE SOLUTION OF $y^{^{\prime \prime \prime }}=f(x,y,y^{\prime },y^{\prime \prime })$ [PDF]

International Journal of Pure and Apllied Mathematics, 2014
F.M. Kolawole, A.O. Adesanya, S.O. Adee
openaire   +1 more source

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

Risk Management in Clinical Laboratory Based on ISO 15189:2022 for Plasma-based Testing of Prothrombin Time and Activated Partial Thromboplastin Time

Dubai Medical Journal
Introduction: In the new ISO 15189:2022 standard, risk management in the clinical laboratory has been hugely emphasized. The purpose of detailed risk analysis and management is to eliminate the known risk factors as much as possible and to minimize the ...
Antony Thomas, Parampreet Kaur, Kavita Krishnan   +2 more
doaj   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Integrating group antenatal care into routine services: a registry-based cohort study in Geita, Tanzania

BMC Global and Public Health
Background Group antenatal care (G-ANC) is an emerging service delivery model that integrates clinical assessments, health education, and peer support within group sessions. While evidence supports its effectiveness in pilot settings, less is known about
Augustino Hellar, Raymond Bandio, Edwin Ernest, Ahmad Makuwani, Alen Kinyina, Phineas Sospeter, Hamid Mandali, Yusuph Kulindwa, Isaac Lyatuu, Wilfred Kafuku, Frank Phiri, Cyprian Mtani, James Tumaini Kengia, Omari Sukari, Husna Athumani, James Hellar, Ntuli Kapologwe   +16 more
doaj   +1 more source

Lărgirea Uniunii Europene: întărirea capacităţii de candidat a României [PDF]

Romanian Journal of European Affairs, 2001
The EU enlargement raises many questions to Member States, among which the institutional framework of the future Europe is a major topic. For the candidate countries, the enlargement raises at least two major issues: (a) what the new Europe would look ...
Eugen Dijmărescu
doaj  

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source