Results 71 to 80 of about 995,884 (279)

On Elements of Sumsets with Many Prime Factors

Journal of Number Theory, 1993
Let \(\nu(n)\) be the number of distinct prime factors of \(n\). The following problem is studied in the paper. Having two finite sets of positive integers \({\mathcal A}\) and \({\mathcal B}\) how big is \(\nu(n)\) on the sumset \({\mathcal A}+{\mathcal B}\)? Suppose that \({\mathcal A}\) and \({\mathcal B}\) are subsets of \(\{n\leq N/2\}\).
Erdos, P., Pomerance, C., Sarkozy, A., Stewart, C.L.   +3 more
openaire   +2 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Computing degree based topological indices of algebraic hypergraphs

Heliyon
Topological indices are numerical parameters that indicate the topology of graphs or hypergraphs. A hypergraph H=(V(H),E(H)) consists of a vertex set V(H) and an edge set E(H), where each edge e∈E(H) is a subset of V(H) with at least two elements.
Amal S. Alali, Esra Öztürk Sözen, Cihat Abdioğlu, Shakir Ali, Elif Eryaşar   +4 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

The effective use of remainder term estimation in the limit theorems

Lietuvos Matematikos Rinkinys, 2003
We investigate the asymptotic behavior of mean value of multiplicative arithmetic function from the class M1(G). In the present paper the asymptotic formula under special condition on prime elements of Knopfmacher’s semigroup G is obtained.
Rimantas Skrabutėnas
doaj   +3 more sources

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Invariable generation with elements of coprime prime-power orders

Journal of Algebra, 2015
A finite group $G$ is coprimely-invariably generated if there exists a set of generators $\{g_1, \ldots, g_d\}$ of $G$ with the property that the orders $|g_1|, \ldots, |g_d|$ are pairwise coprime and that for all $x_1, \ldots, x_d \in G$ the set $\{g_1^{x_1}, \ldots, g_d^{x_d}\}$ generates $G$. In the particular case when $|g_1|, \ldots, |g_d|$ can be
DETOMI, ELOISA MICHELA, LUCCHINI, ANDREA
openaire   +3 more sources