Results 91 to 100 of about 995,884 (279)
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
PRIME LABELING OF AMALGAMATION OF FLOWER GRAPHS
BarekengGraph labeling is the assigning of labels represented by integers or symbols to graph elements, edges and/or vertices (or both) of a graph. Consider a simple graph with a vertex-set and an edge-set .
Desi Rahmadani +4 more
doaj +1 more source
On the infinitude of prime elements
, 2013 Summary: Let \(R\) be an infinite unique factorization domain with at most finitely many units. We discuss the infinitude of prime elements in \(R\) when \(R\) is arbitrary and when \(R\) satisfies the following property: if \(f\) and \(g\) are polynomials with coefficients in \(R\) such that \(f(r)\) divides \(g(r)\) for all \(r \in R\) with \(f(r ...
CÁCERES-DUQUE, LUIS F. +1 more
openaire +3 more sources
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
On Weakly S-Prime Elements of Lattices
Journal of the Indonesian Mathematical SocietyLet £ be a bounded distributive lattice and S a join-subset of £. In this paper, we introduce the concept of S-prime elements (resp. weakly S-prime elements) of £. Let p be an element of £ with S ∧p = 0 (i.e. s∧p = 0 for all s ∈ S). We say that p is an S-prime element (resp.
openaire +2 more sources
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
A Fast and Robust DOA Estimation Method Based on JSVD for Co-Prime Array
IEEE Access, 2018 Compared with the uniform linear array, the co-prime array can obtain a large array aperture with fewer array elements, which is good to improve the accuracy of direction-of-arrival (DOA) estimation.
Xiaopeng Yang +3 more
doaj +1 more source
A very important process of nucleosynthesis in stars [PDF]
When some nuclei are free from strong gravitational field, they are unstable and will become stable nuclei by competitions of following processes: (1) neutron-evaporation; (2) spontaneous fission; and (3) beta prime 3-decay. At the initial stage, (1) and
Yu, C., Zhan, S., Zhou, R.
core +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source