Results 141 to 150 of about 9,843,422 (355)

Pharmacological effects of osimertinib on a chicken chorioallantoic membrane xenograft model with the EGFR exon‐19‐deleted advanced NSCLC mutation

open access: yesFEBS Open Bio, EarlyView.
Osimertinib reduces angiogenesis and PDL1 expression in in ovo tumors, transforming them into ‘cold tumors’ with lower immune activity. Anatomopathological and transcriptomic analyses highlight its therapeutic impact on tumor biology. This study underscores osimertinib's potential to reshape the tumor microenvironment and provides insights into its ...
David Barthélémy   +14 more
wiley   +1 more source

Investigating Schema-Free Encoding of Categorical Data Using Prime Numbers in a Geospatial Context

open access: yesISPRS International Journal of Geo-Information, 2019
Prime numbers are routinely used in a variety of applications, e.g., cryptography and hashing. A prime number can only be divided by one and the number itself.
Martin Sudmanns
doaj   +1 more source

A potential tumor suppressor role of PLK2 in glioblastoma

open access: yesFEBS Open Bio, EarlyView.
PLK2 was consistently downregulated in GBM tissues. Overexpression of PLK2 in GBM cell lines U87MG and U251 reduced their tumorigenic potential and enhanced cell cycle arrest and apoptosis. Suggesting that PLK2 overexpression could potentially be leveraged as a therapeutic strategy to inhibit tumor progression and enhance apoptosis, providing new ...
Xiangping Xia   +5 more
wiley   +1 more source

Distance spectrum of some zero divisor graphs

open access: yesAIMS Mathematics
In the present article, we give the distance spectrum of the zero divisor graphs of the commutative rings $ \mathbb{Z}_{t}[x]/\langle x^{4} \rangle $ ($ t $ is any prime), $ \mathbb{Z}_{t^2}[x] / \langle x^2 \rangle $ ($ t \geq 3 $ is any prime) and ...
Fareeha Jamal , Muhammad Imran
doaj   +1 more source

Red blood cells could protect miRNAs from degradation or loss thanks to Argonaute 2 binding

open access: yesFEBS Open Bio, EarlyView.
The present work investigates the presence and the stability of miRNAs into RBCs, both native and engineered. The observed stability is due to the Ago2 bound resulting in minimal RISC. Indeed, if the miRNA‐Ago2 complex is present, miRNAs are protected from release or degradation and they are biologically active. Thus, RBCs can act as miRNA carriers for
Elena Perla   +4 more
wiley   +1 more source

Ideals in Ordered Γ-Semirings

open access: yesDiscussiones Mathematicae - General Algebra and Applications, 2018
In this paper, we introduce the notion of k-ideal, m−k ideal, prime ideal, maximal ideal, filter, irreducible ideal, strongly irreducible ideal in ordered Γ-semirings, study the properties of ideals in ordered Γ-semirings and the relations between them ...
Rao Marapureddy Murali Krishna
doaj   +1 more source

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