Results 51 to 60 of about 58,134 (302)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Proper Fuzzification of Prime Ideals of a Hemiring

Advances in Fuzzy Systems, 2012
Prime fuzzy ideals, prime fuzzy k-ideals, and prime fuzzy h-ideals are roped in one condition. It is shown that this way better fuzzification is achieved. Other major results of the paper are: every fuzzy ideal (resp., k-ideal, h-ideal) is contained in a
H. V. Kumbhojkar
doaj   +1 more source

Completely Semi Prime Ideal With Respect To An Element Of A Near Ring

Journal of Kufa for Mathematics and Computer, 2011
       In this paper ,we introduce the notions of completely semi prime ideal  with respect to an element x  (x-C.S.P.I)  of  a near ring  and  the completely semi prime ideal  near ring with respect to an element x (x-C.S.P.I ) .  1.
Hussien Hadi Abass, Showq Mhammed Ibraheem   +1 more
doaj   +1 more source

Prime ideals in the quantum grassmannian [PDF]

Selecta Mathematica, 2008
We consider quantum Schubert cells in the quantum grassmannian and give a cell decomposition of the prime spectrum via the Schubert cells. As a consequence, we show that all primes are completely prime in the generic case where the deformation parameter q is not a root of unity. There is a torus H that acts naturally on the quantum grassmannian and the
Launois, Stephane, Lenagan, T.H., Rigal, L.   +2 more
openaire   +2 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

On Rough Fuzzy Prime Ideals in Left Almost Semigroups

International Journal of Analysis and Applications, 2021
In this paper we shall introduce the notion of rough prime ideals and rough fuzzy prime ideals in LA-semigroups. We proved that the lower and the upper approximation of a prime ideal is a prime ideal and we also proved that a fuzzy subset f of an LA ...
Ahmed Elmoasry
doaj  

$0$-ideals in $0$-distributive posets [PDF]

Mathematica Bohemica, 2016
The concept of a $0$-ideal in $0$-distributive posets is introduced. Several properties of $0$-ideals in $0$-distributive posets are established. Further, the interrelationships between $0$-ideals and $\alpha$-ideals in $0$-distributive posets are ...
Khalid A. Mokbel
doaj   +1 more source