Results 71 to 80 of about 1,300,388 (301)

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Intuitionistic fuzzy weakly prime ideals [PDF]

Journal of Hyperstructures, 2017
In this study, the fundamental definitions and theorems regarding intuitionistic fuzzy sets and intuitionistic fuzzy ideals of commutative ring R with identity have been given as preliminaries.
Tu˘gba Arkan, Serkan Onar, Deniz S¨onmez, Bayram Ersoy   +3 more
doaj   +1 more source

Prime Fuzzy Ideals, Weakly Prime Fuzzy Ideals of Γ-semigroups

Fuzzy Information and Engineering, 2013
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Sardar, Sujit Kumar, Pal, Pavel
openaire   +2 more sources

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

On Soft Near-Prime Int-Ideals and Soft 1-Absorbing Prime Int-Ideals With Applications

Journal of Mathematics
In this study, we aimed to introduce two different generalizations of the soft prime int-ideal and clarify the relationships between the soft prime int-ideal and the substructures of a ring. First, we explored new algebraic features of the soft prime int-
İbrahim Halil Kanat, Filiz Çıtak
doaj   +1 more source

On the prime ideal theorem and irregularities in the distribution of primes

Duke Mathematical Journal, 1995
For any fixed \(k\in \mathbb{N}\), let \(f(x)\) denote the polynomial \(x^ k+ Qd\) with \(Q,d\in \mathbb{N}\). Put, for fixed \(Q\) and prime \(p\), \[ \rho(d,p)= |\{m \bmod p;\;m^ k+ Qd\equiv 0\bmod p\}|. \] We factorize \(f\) over \(\mathbb{Q}\) as \(f= \prod_{i=1}^{r(d)} f_ i\), where each \(f_ i\) is irreducible and has integral coefficients, then ...
M. NAIR, PERELLI, ALBERTO
openaire   +3 more sources

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Disjunctive Ideals of Almost Distributive Lattices

Discussiones Mathematicae - General Algebra and Applications, 2022
The concept of disjunctive ideals is introduced in an Almost Distributive Lattice (ADL). It is proved that the set of all disjunctive ideals of an ADL forms a complete lattice.
Rafi N., Srujana M., Rao T. Srinivasa
doaj   +1 more source