Results 91 to 100 of about 612,378 (298)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Uniform prime labeling trees

<p>A prime labeling of a simple finite graph <span class="math inline">\(G\)</span> is a labeling of the vertices with distinct integers from <span class="math inline">\(\{1,2, \dots, |G|\}\)</span> such that the labels of ...
Jing Zhang, Yuan Li
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

The economics of GM food labels: An evaluation of mandatory labeling proposals in India [PDF]

"Labeling of genetically modified (GM) foods is a contentious issue and internationally, there is sharp division whether such labeling ought to be mandatory. This debate has reached India where the government has proposed mandatory labeling.
Ramaswami, Bharat, Bansal, Sangeeta
core  

Prime Labeling Graphs and Hypergraphs

, 2018
Graph labeling problems date back to the beginning of Graph Theory itself (see the Four Color Theorem). Roughly 40 years ago, the notion of a prime labeling of a graph was introduced; a graph on n vertices has a prime labeling if its vertices can be ...
Way, Alan, McCullough, Justin
core   +1 more source

Enhancing Review Processing in the Video Game Adaptation Domain through VADER and Rating-Based Labeling using SVM

Jurnal Sisfokom
The adaptation of video games into films or television series has increasingly become a prominent trend in the entertainment sector, often eliciting diverse reactions from audiences.
Danita Divka Sajmira, Khothibul Umam, Maya Rini Handayani   +2 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Prime Tribe Minutes, Agenda, and Flier

, 2008
Prime Tribe seeks to create and maintain a network, providing support, resources, and information to non-traditional students enrolled at the College of William and ...
Prime Tribe
core  

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Graceful labeling of zero-divisor graph Γ(ℤp²q) and Γ(ℤp³q)

Electronic Journal of Graph Theory and Applications
Some papers have already provided graceful labeling for some types of zero-divisor graphs. We reviewed the graceful labeling results of Γ(ℤ25), Γ(ℤ8), and Γ(ℤ27), then use those results to label zero-divisors graphs Γ(ℤ25q), Γ(ℤ8q), and Γ(ℤ27q).The ...
Christian Constantine, Erma Suwastika
doaj   +1 more source