Results 81 to 90 of about 38,200 (260)

Cyclopropene derivatives of aminosugars for metabolic glycoengineering

Beilstein Journal of Organic Chemistry, 2019
Cyclopropenes have been proven valuable chemical reporter groups for metabolic glycoengineering (MGE). They readily react with tetrazines in an inverse electron-demand Diels–Alder (DAinv) reaction, a prime example of a bioorthogonal ligation reaction ...
Jessica Hassenrück, Valentin Wittmann
doaj   +1 more source

Object Phobia and Altered RhoA Signaling in Amygdala of Mice Lacking RICH2

Frontiers in Molecular Neuroscience, 2017
RICH2 knockout (RICH2 KO) mice exhibit neophobia in the novel object test. To gain further insight into their anxiety-related phenotype, we subjected these mice to additional behavioral tests to elucidate whether the behavioral abnormality in these mice ...
Tasnuva Sarowar, Stefanie Grabrucker, Tobias M. Boeckers, Andreas M. Grabrucker, Andreas M. Grabrucker   +4 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Overcoming Challenges and Opening New Opportunities in Glycoproteomics

Biomolecules, 2013
Glycoproteomics has emerged as a prime area of interest within the field of proteomics because glycoproteins have been shown to function as biomarkers for disease and as promising therapeutic targets. A significant challenge in the study of glycoproteins
Bruce A. Macher, Leslie C. Timpe, Alejandro A. Corona, Sucharita M. Dutta, Christina Litsakos-Cheung, Ten-Yang Yen   +5 more
doaj   +1 more source

On Prime Labeling Of Herschel Graph

, 2016
A graph with vertex set is said to have a prime labeling if its vertices are labeled with distinct integers such that for each the labels assigned to and are relatively prime. A graph which admits prime labeling is called a prime graph.In this paper, we investigate prime labeling of Herschel graph.
V. Ganesan, Dr. K. Balamurugan
openaire   +2 more sources

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Dynamic Metabolomics Reveals that Insulin Primes the Adipocyte for Glucose Metabolism

Cell Reports, 2017
Summary: Insulin triggers an extensive signaling cascade to coordinate adipocyte glucose metabolism. It is considered that the major role of insulin is to provide anabolic substrates by activating GLUT4-dependent glucose uptake.
James R. Krycer, Katsuyuki Yugi, Akiyoshi Hirayama, Daniel J. Fazakerley, Lake-Ee Quek, Richard Scalzo, Satoshi Ohno, Mark P. Hodson, Satsuki Ikeda, Futaba Shoji, Kumi Suzuki, Westa Domanova, Benjamin L. Parker, Marin E. Nelson, Sean J. Humphrey, Nigel Turner, Kyle L. Hoehn, Gregory J. Cooney, Tomoyoshi Soga, Shinya Kuroda, David E. James   +20 more
doaj   +1 more source

Prime labelings of infinite graphs

Involve, a Journal of Mathematics, 2019
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Kenigsberg, Matthew, Levin, Oscar
openaire   +2 more sources

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Un-Islamic or Non-Muslim

American Journal of Islam and Society, 2015
The reality is that the Islamic State is Islamic. Very Islamic. Yes, it has attracted psychopaths and adventure seekers, drawn largely from the disaffected populations of the Middle East and Europe.
Zakyi Ibrahim
doaj   +1 more source