Results 71 to 80 of about 2,726,364 (271)
Commutativity of near-rings with (σ;τ)-derivations
Analele Stiintifice ale Universitatii Ovidius Constanta: Seria Matematica, 2013 In this paper we study some conditions under which a near-ring R admitting a (multiplicative) (σ; τ )-derivation d must be a commutative ring with constrained-suitable conditions on d, σ and τ.
Kamal Ahmed A. M., Al-Shaalan Khalid H.
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Distributive near-rings with minimal square
, 1987 There exist many examples of distributive near-rings such that their square generates a minimal left N-subgroup of N. Here it is shown that a near-ring belongs to this class if and only if it is the semi-direct sum of a zero near-ring and a skew ...
S. Di Sieno, S. De Stefano
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FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
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Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
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PRIME GAMMA NEAR-RINGS WITH DERIVATIONS [PDF]
International Journal of Pure and Apllied Mathematics, 2013 Let N be a prime Γnear-ring with the center Z(N). The objective of this paper is to study derivations on N. We prove two results: (a) Let N be 2-torsion free and let D1 and D2 be derivations on N such that D1D2 is also a derivation. Then D1 = 0 or D2 = 0 if and only if[D1(x), D2(y)]α = 0 for all x, y ∈ N, α ∈ Γ; b) Let n be an integer greater than 1,
Rakhimov, Isamiddin Sattarovich +2 more
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$(\sigma,\tau)$-derivations on prime near rings
, 2004 summary:There is an increasing body of evidence that prime near-rings with derivations have ring like behavior, indeed, there are several results (see for example [1], [2], [3], [4], [5] and [8]) asserting that the existence of a suitably-constrained ...
Ali, Shakir, Ashraf, Mohammad, Ali, Asma
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Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
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Geophysical Research Letters, 2018 The New Horizons encounter with the cold classical Kuiper Belt object 2014 MU69 (informally named “Ultima Thule,” hereafter Ultima) on 1 January 2019 will be the first time a spacecraft has ever closely observed one of the free‐orbiting small denizens of
Jeffrey M. Moore +33 more
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Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
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