Results 171 to 180 of about 147,553 (263)

MF59-adjuvanted A/Astrakhan influenza vaccine induces cross-neutralizing H5N1 antibodies in ferrets against circulating clade 2.3.4.4b viruses. [PDF]

NPJ Vaccines
Segovia K, Rathnasinghe R, Patton C, Kwon B, Longstaff RA, Hofmann D, Banger KK, Xu H, Lacey M, Settembre E, Palladino G, Kennedy AT, Music N.   +12 more
europepmc   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Improved VSV-Ebola-GP booster vaccination approach promotes antibody affinity maturation and durable anti-Ebola immunity in humans. [PDF]

Nat Immunol
Khurana S, Posadas O, Kardava L, Coyle EM, Ravichandran S, Grubbs G, McConnell R, Rouphael N, Poliquin G, Langley JM, Chu E, Follmann DA, Shang X, Li Y, Moir S, Davey RT.   +15 more
europepmc   +1 more source

Prime number theorem analogues without primes.

Journal für die reine und angewandte Mathematik (Crelles Journal), 1974
openaire   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

<i>Planes</i> on a Snake? On the Identities of Crab Larvae Rafting on Sea Snakes. [PDF]

Ecol Evol
Elefánti S, Lasley R, Paulay G, Pfaller JB.   +3 more
europepmc   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Prime editing of a pathogenic <i>Scn1a</i> allele ameliorates seizure phenotypes in a GEFS⁺ mouse model. [PDF]

Sci Transl Med
Kissling L, Pietrafesa F, Ranucci M, Böck D, Mathis N, Kulcsár PI, Ioannidi E, Schmidheini L, Tálas A, Villiger E, Wildner H, Zhao X, Kompotis K, Zeilhofer HU, Schwank G.   +14 more
europepmc   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source