Results 151 to 160 of about 156,880 (305)
Prime Number Sieving—A Systematic Review with Performance Analysis
AlgorithmsThe systematic generation of prime numbers has been almost ignored since the 1990s, when most of the IT research resources related to prime numbers migrated to studies on the use of very large primes for cryptography, and little effort was made to ...
Mircea Ghidarcea, Decebal Popescu
doaj +1 more source
17 and 23: prime numbers for ankylosing spondylitis? [PDF]
Lancet, 2013 Colbert RA, Ward MM.
europepmc +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Prime numbers, post infinity and imaginary numbers
This paper talks about a hypothesis that after the infinity of real numbers follows the post infinity, and that this post infinity is in the "imaginary" plane, and that through this we can relate and better understand prime numbers, real numbers ...
Kaoru Aguilera Katayama
core +1 more source
Distribution of Square Prime Numbers
For $a \neq 1$ and $p$ prime, we define numbers of the form $pa^2$ to be Square-Prime (SP) Numbers. For example, 75 = 3 $\cdot$ 25; 108 = 3 $\cdot$ 36; 45 = 5 $\cdot$ 9. These numbers are listed in the OEIS as A228056.
Bhat, Raghavendra N.
core +1 more source
Natural numbers and prime numbers: a conjecture
, 2020 We state a conjecture about natural and prime ...
Mayeux, Arnaud
core