Results 131 to 140 of about 156,880 (305)
Prime Numbers and Polynomials.
, 2010 This thesis deals with the classical problem of prime numbers represented by polynomials. It consists of three parts. In the first part I collected many results about the problem. Some of them are quite recent and this part can be considered as a survey of the state of the art of the subject. In the second part I present two results due to P. Pleasants
openaire +2 more sources
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
The Effect of the Density of Square-Free ωp-numbers on the Bounds of Beurling Counting Function
Zanco Journal of Pure and Applied SciencesPrimitive weird numbers are weird numbers which are not a multiple of any smaller weird numbers. The goal of this work is to use a square-free primitive weird number x=ab where b be an increasing sequence of prime numbers such that q1 is greater than ∏
Sarah Al-Ebrahimy, Eman F. Mohommed
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Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
A Class of Bounded Iterative Sequences of Integers
AxiomsIn this note, we show that, for any real number τ∈[12,1), any finite set of positive integers K and any integer s1≥2, the sequence of integers s1,s2,s3,… satisfying si+1−si∈K if si is a prime number, and 2≤si+1≤τsi if si is a composite number, is bounded
Artūras Dubickas
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Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Obtaining absolute prime numbers
, 2002 This thesis is an exposition of the articles entitled Absolute Prime Numbers by Dmitry Mavlo, which appeared in the Mathematical Gazette, Vol. 79, published in the year 1995 and Absolute Primes by A.
Alcera, Aubrey C., Pe, Tobie Ivan A.
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