Results 111 to 120 of about 1,769,019 (256)
Prime Numbers Networks: Visualizing and Characterizing Relationships Between Prime Numbers
, 2023 Prime numbers constitute mathematical concepts of particular interest as a consequence of the their relative paucity among integer values, as well as to the relative unpredictability of their appearance and density along the sequence of integer values ...
da Fontoura Costa, Luciano
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Prime Numbers: Riddles and Applications
, 2019 This work offers an overview of the mysteries and applications of the most important numbers in mathematics: prime ...
José de Jesús Camacho Medina
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MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
The Effect of the Density of Square-Free ωp-numbers on the Bounds of Beurling Counting Function
Zanco Journal of Pure and Applied SciencesPrimitive weird numbers are weird numbers which are not a multiple of any smaller weird numbers. The goal of this work is to use a square-free primitive weird number x=ab where b be an increasing sequence of prime numbers such that q1 is greater than ∏
Sarah Al-Ebrahimy, Eman F. Mohommed
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
A Class of Bounded Iterative Sequences of Integers
AxiomsIn this note, we show that, for any real number τ∈[12,1), any finite set of positive integers K and any integer s1≥2, the sequence of integers s1,s2,s3,… satisfying si+1−si∈K if si is a prime number, and 2≤si+1≤τsi if si is a composite number, is bounded
Artūras Dubickas
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Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
About Interval Estimations of the Prime Numbers Maintenance
Безопасность информационных технологий, 2011 In the article, within the framework of confidential information protection tasks, the model of prime and compound numbers formation in an interval ...
V. A. Minaev
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