Results 91 to 100 of about 1,769,019 (256)

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

On an inequality about Euler's totient function [PDF]

Notes on Number Theory and Discrete Mathematics
In this paper, we show that when Nₖ is a primorial and φ(Nₖ) is Euler's totient function, the inequality φ(Nₖ)44.
Cheng-Ting Wang
doaj   +1 more source

Along the Lines of Nonadditive Entropies: q-Prime Numbers and q-Zeta Functions. [PDF]

Entropy (Basel), 2021
Borges EP, Kodama T, Tsallis C.
europepmc   +1 more source

DNA ligase LigE increases bacterial transformation with damaged extracellular DNA

FEBS Letters, EarlyView.
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan, Avi Singh, Shrawani Weralupe Gamladdalage, Joanna Hicks, Adele Williamson   +4 more
wiley   +1 more source

Computational challenges and solutions: Prime number generation for enhanced data security.

PLoS ONE
This paper addresses the computational methods and challenges associated with prime number generation, a critical component in encryption algorithms for ensuring data security.
Amal Ezz-Eldien, Mohamed Ezz, Amjad Alsirhani, Ayman Mohamed Mostafa, Abdullah Alomari, Faeiz Alserhani, Mohammed Mujib Alshahrani   +6 more
doaj   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

On the emergence of the Quanta Prime sequence

Arab Journal of Basic and Applied Sciences
This paper presents the Quanta Prime Sequence (QPS) and its foundational theorem, showcasing a unique class of polynomials with substantial implications.
Moustafa Ibrahim
doaj   +1 more source

Mersenne Primes in Certain Lucas Sequences [PDF]

EPJ Web of Conferences
Prime numbers are the most important numbers in number theory and cryptography. One of such special primes are given by the set of Mersenne primes, that are derived from the form Mn = 2n − 1, where n is a prime number.
Hadi Ahmed H., Hashim Hayder R.
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

A note on Sturm-Liouville problems whose spectrum is the set of prime numbers

Electronic Journal of Differential Equations, 2011
We show that there is no classical regular Sturm-Liouville problem on a finite interval whose spectrum consists of infinitely many distinct primes numbers. In particular, this answers in the negative a question raised by Zettl in his book [9].
Angelo B. Mingarelli
doaj