Results 61 to 70 of about 78,445 (293)

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Quasirecognition by prime graph of finite simple groups ${}^2D_n(3)$ [PDF]

International Journal of Group Theory, 2014
Let $G$ be a finite group. In [Ghasemabadi et al., characterizations of the simple group ${}^2D_n(3)$ by prime graph and spectrum, Monatsh Math., 2011] it is proved that if $n$ is odd, then ${}^2D _n(3)$ is recognizable by prime graph and also by ...
Behrooz Khosravi , Hossein Moradi
doaj  

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Invariant prime ideals in equivariant Lazard rings [PDF]

, 2023
Let $A$ be an abelian compact Lie group. In this paper we compute the spectrum of invariant prime ideals of the $A$-equivariant Lazard ring, or equivalently the spectrum of points of the moduli stack of $A$-equivariant formal groups. We further show that
Meier, Lennart, Hausmann, Markus
core   +1 more source

Eigenvalues of Sturm-Liouville operators and prime numbers

Electronic Journal of Differential Equations, 2017
We show that there is no function $q(x)\in L_2(0,1)$ which is the potential of a Sturm-Liouville problem with Dirichlet boundary condition whose spectrum is a set depending nonlinearly on the set of prime numbers as suggested by Mingarelli [7].
Rauf Amirov, Ibrahim Adalar
doaj  

On the Seidel spectrum of the total graphs of the rings of integers modulo n

Mathematics Open
In this paper, we study the Seidel spectrum of the total graph [Formula: see text] for various values of n. For [Formula: see text], with p prime, we give a complete spectral description and show that the spectrum is integral if and only if [Formula: see
Akhil P, Raisa DSouza
doaj   +1 more source

The quantum euclidean algebra and its prime spectrum [PDF]

, 2017
For the quantum Euclidean algebra, its prime, completely prime and maximal spectra are described (together with inclusions of prime ideals). The centre is generated by two algebraically independent elements (one is quadratic and the other is cubic)
Lu, T., Bavula, V.V., T. Lu, V. V. Bavula   +3 more
core   +1 more source