Results 211 to 220 of about 521,451 (294)

Prime Numbers [PDF]

Notices of the International Congress of Chinese Mathematicians, 2013
openaire   +2 more sources

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

A practical guide to targeted single-cell RNA sequencing technologies. [PDF]

Commun Biol
Moro G, Brunner E, Basler K.
europepmc   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Editorial – Wound recognition across the tree of life

Frontiers in Plant Science, 2016
Martin Heil, Walter Gottlieb Land, Mahmut Tör   +2 more
doaj   +1 more source

Alumina Priming-Mediated Enhanced Binding of Diethylzinc with Carbonyl Groups in Poly(Methyl Methacrylate) during Vapor-Phase Infiltration. [PDF]

Chem Mater
Tiwale N, Subramanian A, Sikder S, Qu X, Freychet G, Gann E, Jaye C, Kisslinger K, Boscoboinik JA, Nam CY.   +9 more
europepmc   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Enhancement of Apiaceae pre-germination embryo growth, mericarp ageing resilience and germination differs between hormone, gas plasma, and hydropriming technologies. [PDF]

Planta
Fatelnig LMM, Walker M, Grainge G, Hourston JE, Kennedy S, Turečková V, Novák O, Tarkowská D, Strnad M, Nakabayashi K, Steinbrecher T, Leubner-Metzger G.   +11 more
europepmc   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

<i>Shigella</i> OspF blocks rapid p38-dependent priming of the NAIP-NLRC4 inflammasome. [PDF]

Proc Natl Acad Sci U S A
Turcotte EA, Kim K, Eislmayr KD, Goers L, Mitchell PS, Lesser CF, Vance RE.   +6 more
europepmc   +1 more source