Results 61 to 70 of about 243,902 (282)
Regional determinants of residential energy expenditures and the principal-agent problem in Austria
REGION, 2015 The aim of this paper is two-fold: 1) to examine the determinants of residential energy expenditures and compare them on a regional level; and, 2) attempt to identify and measure the effect of possible principal-agent (PA) problems on residential energy ...
Daniel R. Hill
doaj
National Hockey League guaranteed contracts: A principal agent problem impacting on performance [PDF]
, 2015 Purpose – This paper aims to investigate, through the lens of the principal–agent problem, the relationship between payment of National Hockey League (NHL) salaries and player performance during the period of 2005-2011 and explore the inherent issues ...
Edgar, David +3 more
core +1 more source
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
Reinvention and the Principal-Agent Model
Convergencia, 2003 Existe una interesante polémica en el sector público, derivada de las tensiones existentes entre desempeño y flexibilidad administrativa por un lado, y rendición de cuentas y control, por el otro.
J. Ramón Gil García
doaj
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Solution Concepts of Principal-Agent Models with Unawareness of Actions
Games, 2013 In numerous economic scenarios, contracting parties may not have a clear picture of all the relevant aspects. A contracting party may be unaware of what she and/or others are entitled to determine. Therefore, she may reject a contract that is too good to
Xiaojian Zhao, Ying-Ju Chen
doaj +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
A model of desertion. From a principal-agent theory perspective
Cuadernos de Economía, 2017 Este artículo estudia la naturaleza de trade-off entre los incentives y los mecanismos de autocumplimento que el líder de una organización armada ilegal, quien actúa como principal, ofrece a sus operativos, quienes son los agentes. El modelo de principal-
María Del Pilar Castillo Valencia +1 more
doaj +1 more source
The role of histone modifications in transcription regulation upon DNA damage
FEBS Letters, EarlyView.This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley +1 more source