Results 91 to 100 of about 226,801 (347)
The power of microRNA regulation—insights into immunity and metabolism
FEBS Letters, EarlyView.MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto +2 more
wiley +1 more source
Identification of novel small molecule inhibitors of ETS transcription factors
FEBS Letters, EarlyView.ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla +9 more
wiley +1 more source
The Saccharomyces cerevisiae amino acid transporter Lyp1 has a broad substrate spectrum
FEBS Letters, EarlyView.In Saccharomyces cerevisiae, Yeast Amino acid Transporter family members mediate the import of amino acids, ranging from substrate specialists to generalists. Here, we show that the specialist transporter, Lyp1, has a broader substrate spectrum than previously described, with affinity constants spanning from micromolar to millimolar.
Foteini Karapanagioti +3 more
wiley +1 more source
Stability of the matrix model in operator interpretation
Nuclear Physics B, 2017 The IIB matrix model is one of the candidates for nonperturbative formulation of string theory, and it is believed that the model contains gravitational degrees of freedom in some manner.
Katsuta Sakai
doaj
Interaction between axons and specific populations of surrounding cells is indispensable for collateral formation in the mammillary system. [PDF]
PLoS ONE, 2011 An essential phenomenon during brain development is the extension of long collateral branches by axons. How the local cellular environment contributes to the initial sprouting of these branches in specific points of an axonal shaft remains unclear.The ...
Nora-Emöke Szabó +5 more
doaj +1 more source
The Atiyah bundle and connections on a principal bundle
Proceedings - Mathematical Sciences, 2010 Let M be a C∞ manifold and G a Lie a group. Let EG be a C∞ principal G-bundle over M. There is a fiber bundle C(EG) over M whose smooth sections correspond to the connections on EG. The pull back of EG to C(EG) has a tautological connection. We investigate the curvature of this tautological connection.
openaire +2 more sources
Molecular Oncology, EarlyView.The number of circulating tumor cells obtained from prostate cancer patients was increased approximately 5‐fold compared to regular CellSearch when processing 2 mL diagnostic leukapheresis material aliquots and increased by 44‐fold when processing 20 mL DLA aliquots using the flow enrichment target capture Halbach‐array.
Michiel Stevens +8 more
wiley +1 more source
Classification of Bundle Branch Blocks with QRS Templates Extracted from 12-lead ECGs
Current Directions in Biomedical Engineering, 2021 Being non-invasive, cheap and widely available, the 12-lead electrocardiogram (ECG) is a standard method to assess cardiac function. Still, its reliable interpretation requires specialized knowledge and experience, rendering a second opinion valuable. We
Welle Hannes +4 more
doaj +1 more source
On semistable principal bundles over a complex projective manifold, II
, 2008 Let (X, \omega) be a compact connected Kaehler manifold of complex dimension d and E_G a holomorphic principal G-bundle on X, where G is a connected reductive linear algebraic group defined over C. Let Z (G) denote the center of G.
A. Ramanathan +13 more
core +2 more sources
Molecular Oncology, EarlyView.Cancer‐associated fibroblasts (CAFs) promote cancer growth, invasion (metastasis), and drug resistance. Here, we identified functional and diverse circulating CAFs (cCAFs) in patients with metastatic prostate cancer (mPCa). cCAFs were found in higher numbers and were functional and diverse in mPCa patients versus healthy individuals, suggesting their ...
Richell Booijink +6 more
wiley +1 more source