Results 51 to 60 of about 811,918 (310)

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

open access: yesMolecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian   +10 more
wiley   +1 more source

PCAtest: testing the statistical significance of Principal Component Analysis in R

open access: yesPeerJ, 2022
Principal Component Analysis (PCA) is one of the most broadly used statistical methods for the ordination and dimensionality-reduction of multivariate datasets across many scientific disciplines.
Arley Camargo
semanticscholar   +1 more source

The principal independent components of images [PDF]

open access: yes, 2010
This paper proposes a new approach for the encoding of images by only a few important components. Classically, this is done by the Principal Component Analysis (PCA).
Arlt, Björn, Brause, Rüdiger W.
core  

Analysis of the principal component algorithm in phase-shifting interferometry [PDF]

open access: yes, 2011
We recently presented a new asynchronous demodulation method for phase-sampling interferometry. The method is based in the principal component analysis (PCA) technique. In the former work, the PCA method was derived heuristically.
Belenguer Dávila, Tomás   +2 more
core   +2 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

Community awareness about disaster preparedness: Principal component analysis (PCA)

open access: yesMajmaah Journal of Health Sciences, 2021
Background and Aim: Responsibility for disaster preparedness is not limit- ed to healthcare institutions and healthcare providers; communities must also be involved. Knowledge of community members’ awareness of disaster preparedness will enhance and strengthen a community’s resilience to disaster.
Abdullelah Thobaity, Modi Moteri
openaire   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

open access: yesMolecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero   +11 more
wiley   +1 more source

Multiscale principal component analysis

open access: yes, 2013
Principal component analysis (PCA) is an important tool in exploring data. The conventional approach to PCA leads to a solution which favours the structures with large variances.
Akinduko, A. A., Gorban, A. N.
core   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

open access: yesMolecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang   +8 more
wiley   +1 more source

Weighted SNP set analysis in genome-wide association study. [PDF]

open access: yesPLoS ONE, 2013
Genome-wide association studies (GWAS) are popular for identifying genetic variants which are associated with disease risk. Many approaches have been proposed to test multiple single nucleotide polymorphisms (SNPs) in a region simultaneously which ...
Hui Dai   +9 more
doaj   +1 more source

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