Results 141 to 150 of about 2,352,425 (243)

Quantitative determination of trace principal components with high specific activity in menotropins. [PDF]

Front Bioeng Biotechnol
Sun Y, Li H, Hu X, Luo S, Zhang X, Wang L, Li Y, Lyu P, Li J.   +8 more
europepmc   +1 more source

Multilevel hybrid principal components analysis for region-referenced functional electroencephalography data. [PDF]

Stat Med, 2022
Campos E, Wolfe Scheffler A, Telesca D, Sugar C, DiStefano C, Jeste S, Levin AR, Naples A, Webb SJ, Shic F, Dawson G, Faja S, McPartland JC, Şentürk D, Autism Biomarkers Consortium for Clinical Trials.   +14 more
europepmc   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Controllable protein design via autoregressive direct coupling analysis conditioned on principal components. [PDF]

PLoS Comput Biol
Caredda F, Gennai L, De Los Rios P, Pagnani A.   +3 more
europepmc   +1 more source

ERStruct: a fast Python package for inferring the number of top principal components from whole genome sequencing data. [PDF]

BMC Bioinformatics, 2023
Yang J, Xu Y, Yao M, Wang G, Liu Z.
europepmc   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Association of Nontraditional Lipid Parameters With Long-Term Prognosis of Acute Ischemic Stroke: A Principal Components Analysis. [PDF]

J Am Heart Assoc
Lin H, Xie W, Huang S, Lou J, Zhang R, Yu B, Zhou G, Pan Y, Wu T, Huang X, Chen F, Zhang C, Zhu Y, Weng Y, Yang D, Chen G.   +15 more
europepmc   +1 more source

Principal components from untargeted cerebrospinal fluid metabolomics associated with Alzheimer's disease biomarkers. [PDF]

Neurobiol Aging, 2022
Dong R, Denier-Fields DN, Lu Q, Suridjan I, Kollmorgen G, Wild N, Betthauser TJ, Carlsson CM, Asthana S, Johnson SC, Zetterberg H, Blennow K, Engelman CD.   +12 more
europepmc   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

randPedPCA: rapid approximation of principal components from large pedigrees. [PDF]

Genet Sel Evol
Lee H, Craddock RF, Gorjanc G, Becher H.
europepmc   +1 more source