Results 151 to 160 of about 2,352,425 (243)

Bayesian multivariate sparse functional principal components analysis with application to longitudinal microbiome multiomics data. [PDF]

Ann Appl Stat, 2022
Jiang L, Elrod C, Kim JJ, Swafford AD, Knight R, Thompson WK.   +5 more
europepmc   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Matching heterogeneous cohorts by projected principal components reveals two novel Alzheimer's disease-associated genes in the Hispanic population. [PDF]

Alzheimers Dement
Willett JDS, Waqas M, Naumenko S, Mullin K, Hecker J, Bertram L, Lange C, Vlachos I, Hide W, Tanzi RE, Prokopenko D.   +10 more
europepmc   +1 more source

A practical introduction to EEG Time-Frequency Principal Components Analysis (TF-PCA). [PDF]

Dev Cogn Neurosci, 2022
Buzzell GA, Niu Y, Aviyente S, Bernat E.
europepmc   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Contrastive Functional Principal Components Analysis. [PDF]

Proc AAAI Conf Artif Intell
Zhang E, Li D.
europepmc   +1 more source

An Exploration of Pathologies of Multilevel Principal Components Analysis in Statistical Models of Shape. [PDF]

J Imaging, 2022
Farnell DJJ.
europepmc   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Principal components-based selection criteria for genetic improvement of growth in sheep breeding programs. [PDF]

Genet Sel Evol
Mandal A, Gayari I, Lalhmingmawii S, Notter DR, Baneh H.   +4 more
europepmc   +1 more source

Detecting gene-gene interactions from GWAS using diffusion kernel principal components. [PDF]

BMC Bioinformatics, 2022
Walakira A, Ocira J, Duroux D, Fouladi R, Moškon M, Rozman D, Van Steen K.   +6 more
europepmc   +1 more source