Results 151 to 160 of about 5,566,031 (259)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Quantitative determination of trace principal components with high specific activity in menotropins. [PDF]

Front Bioeng Biotechnol
Sun Y, Li H, Hu X, Luo S, Zhang X, Wang L, Li Y, Lyu P, Li J.   +8 more
europepmc   +1 more source

The metabolic spatial covariance pattern of definite idiopathic normal pressure hydrocephalus: an FDG PET study with principal components analysis. [PDF]

Alzheimers Res Ther, 2023
Rau A, Schröter N, Blazhenets G, Maurer C, Urbach H, Meyer PT, Frings L.   +6 more
europepmc   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Growth Regressions, Principal Components and Frequentist Model Averaging [PDF]

This paper offers two innovations for empirical growth research. First, the paper discusses principal components augmented regressions to take into account all available information in well-behaved regressions.
Hlouskova, Jaroslava, Wagner, Martin
core  

Using Principal Components Analysis to Visualize Motion and Mitigate Artifacts in Dynamic Optical Coherence Tomography. [PDF]

J Biophotonics
Jiménez AM, Bradu A.
europepmc   +1 more source

The Application of Clustering on Principal Components for Nutritional Epidemiology: A Workflow to Derive Dietary Patterns. [PDF]

Nutrients, 2022
Maugeri A, Barchitta M, Favara G, La Mastra C, La Rosa MC, Magnano San Lio R, Agodi A.   +6 more
europepmc   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Improved Construction of diffusion indexes for macroeconomic forecasting [PDF]

This article proposes a modified method for the construction of diffusionindexes in macroeconomic forecasting using principal component regres-sion. The method aims to maximize the amount of variance of the origi-nal predictor variables retained by the ...
Dijk, D.J.C. van, Groenen, P.J.F., Heij, C.   +2 more
core  

The longitudinal structure of cognition in the ABCD study and associations with neural function and psychopathology: A Bayesian probabilistic principal components analysis. [PDF]

Dev Cogn Neurosci
Luciana M, Duffy KA, Thompson WK.
europepmc   +1 more source