Results 81 to 90 of about 2,352,425 (243)
Estimating Common Principal Components in High Dimensions
We consider the problem of minimizing an objective function that depends on an orthonormal matrix. This situation is encountered when looking for common principal components, for example, and the Flury method is a popular approach.
Browne, Ryan P., McNicholas, Paul D.
core +2 more sources
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Genetic variation among diverse safflower genotypes for some agro-morphological traits
Oilseeds and fats, crops and lipidsThis study sought to investigate the genetic diversity among 100 safflower genotypes concerning seed yield performance and seventeen morphological traits and yield components.
Sabaghnia Naser +2 more
doaj +1 more source
FEBS Letters, EarlyView.The pyruvate generator, which causes activation of respiration by extra‐mitochondrial Ca2+, is also present and functional in rat brainstem mitochondria, as it is in other brain regions. This finding is confirmed by experiments with a fully reconstituted malate–aspartate shuttle (MAS).
Grazyna Debska‐Vielhaber +7 more
wiley +1 more source
Optimal detection of sparse principal components in high dimension
We perform a finite sample analysis of the detection levels for sparse principal components of a high-dimensional covariance matrix. Our minimax optimal test is based on a sparse eigenvalue statistic.
Berthet, Quentin, Rigollet, Philippe
core +2 more sources
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Pattern classification using principal components regression [PDF]
In this paper we will classify patterns using an algorithm analogous to the k-means algorithm and the principal components regression (PCR). We will also present a financial application in which we apply PCR if the points represent the interests for ...
Ciuiu, Daniel
core
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Spurious Principal Components [PDF]
The Principal Component Regression is often used to forecast macroeconomic variables when there are many predictors. In this letter, we argue that it makes sense to pre-whiten the predictors before including these in a PCR. With simulation experiments,
Franses, Ph.H.B.F. (Philip Hans) +1 more
core
CMB Constraints on Principal Components of the Inflaton Potential
We place functional constraints on the shape of the inflaton potential from the cosmic microwave background through a variant of the generalized slow roll approximation that allows large amplitude, rapidly changing deviations from scale-free conditions ...
Cora Dvorkin, S. M. Leach, Wayne Hu
core +2 more sources