Results 91 to 100 of about 2,294,043 (337)

Principal Component Projection Without Principal Component Analysis

, 2016
We show how to efficiently project a vector onto the top principal components of a matrix, without explicitly computing these components. Specifically, we introduce an iterative algorithm that provably computes the projection using few calls to any black-box routine for ridge regression.
Frostig, Roy, Musco, Cameron, Musco, Christopher, Sidford, Aaron   +3 more
openaire   +2 more sources

Principals about principal components in statistical genetics

Briefings in Bioinformatics, 2018
AbstractPrincipal components (PCs) are widely used in statistics and refer to a relatively small number of uncorrelated variables derived from an initial pool of variables, while explaining as much of the total variance as possible. Also in statistical genetics, principal component analysis (PCA) is a popular technique.
Abegaz, Fentaw, Chaichoompu, Kridsadakorn, Genin, Emmanuelle, Fardo, David W., König, Inke R., Mahachie John, Jestinah M., Van Steen, Kristel   +6 more
openaire   +4 more sources

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

FEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang, Naoki Sunagawa, Toma Kashima, Kiyohiko Igarashi, Akimasa Miyanaga, Shinya Fushinobu   +5 more
wiley   +1 more source

A Motor Imagery EEG Feature Extraction Method Based on Energy Principal Component Analysis and Deep Belief Networks [PDF]

, 2020
Liwei Cheng, Duanling Li, Gongjing Yu, Zhonghai Zhang, xiang li, Shuyue Yu   +5 more
openalex   +1 more source

The zinc finger domains of PARP‐1 are selectively and potently inhibited by the Au(I)‐based drugs sodium aurothiomalate and aurothioglucose

FEBS Letters, EarlyView.
PARP‐1 is a key enzyme in the DNA damage response, and its inhibition induces cancer cell death via synthetic lethality. Au(I)‐based drugs, such as aurothioglucose and sodium aurothiomalate, block PARP‐1's DNA‐dependent activity by targeting its zinc finger domains.
Uliana Bashtanova, Melinda Jane Duer
wiley   +1 more source

Dynamic functional principal components [PDF]

, 2012
In this paper, we address the problem of dimension reduction for sequentially observed functional data (X_k : k ∈ Z). Such functional time series arise frequently, e.g., when a continuous time process is segmented into some smaller natural units, such
Hallin, Marc, Hörmann, Siegfried, Kidzinski, Lukasz   +2 more
core  

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Chemomertic Risk Assessment of Soil Pollution

Open Chemistry, 2019
In this study, an interpretation and modeling of the soil quality by monitoring data using an intelligent data analysis is presented. On an annual average, values of 12 soil surface chemical parameters as input variables were determined at 35 sampling ...
Nedyalkova Miroslava, Simeonov Vasil
doaj   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

A New Feature Extraction Method Based on the Information Fusion of Entropy Matrix and Covariance Matrix and Its Application in Face Recognition

Entropy, 2015
The classic principal components analysis (PCA), kernel PCA (KPCA) and linear discriminant analysis (LDA) feature extraction methods evaluate the importance of components according to their covariance contribution, not considering the entropy ...
Shunfang Wang, Ping Liu
doaj   +1 more source