Results 101 to 110 of about 2,367,896 (336)
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Targeted principal components regression
Journal of Multivariate Analysis, 2022 We propose a principal components regression method based on maximizing a joint pseudo-likelihood for responses and predictors. Our method uses both responses and predictors to select linear combinations of the predictors relevant for the regression, thereby addressing an oft-cited deficiency of conventional principal components regression.
openaire +3 more sources
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Dynamic functional principal components [PDF]
, 2012 In this paper, we address the problem of dimension reduction for sequentially observed functional data (X_k : k ∈ Z). Such functional time series arise frequently, e.g., when a continuous time process is segmented into some smaller natural units, such
Hallin, Marc +2 more
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Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Mapping discourses through Hierarchical Clustering on Principal Components
Methodological InnovationsThis article proposes a methodological framework that combines a Q-concourse questionnaire with Multiple Factor Analysis and Hierarchical Clustering on Principal Components (MFA/HCPC) to derive discourse typologies from large-N survey data. The framework
Francesco Veri
doaj +1 more source
Incorporating Prior Knowledge of Principal Components in Genomic Prediction
Frontiers in Genetics, 2018 Genomic prediction using a large number of markers is challenging, due to the curse of dimensionality as well as multicollinearity arising from linkage disequilibrium between markers.
Sayed M. Hosseini-Vardanjani +3 more
doaj +1 more source
Image encoding by independent principal components [PDF]
, 2010 The encoding of images by semantic entities is still an unresolved task. This paper proposes the encoding of images by only a few important components or image primitives. Classically, this can be done by the Principal Component Analysis (PCA). Recently,
Arlt, Björn, Brause, Rüdiger W.
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