Results 111 to 120 of about 2,367,896 (336)

Integrated Principal Components Analysis

, 2018
Data integration, or the strategic analysis of multiple sources of data simultaneously, can often lead to discoveries that may be hidden in individualistic analyses of a single data source. We develop a new unsupervised data integration method named Integrated Principal Components Analysis (iPCA), which is a model-based generalization of PCA and serves
Tang, Tiffany M., Allen, Genevera I.
openaire   +3 more sources

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Spatial and multivariate analysis of soybean productivity and soil physical-chemical attributes

Revista Brasileira de Engenharia Agrícola e Ambiental
The objective of this study was to evaluate the spatial variability of soybean yield, carbon stock, and soil physical attributes using multivariate and geostatistical techniques.
Ricardo N. Buss, Raimunda A. Silva, Glécio M. Siqueira, Jairo O. R. Leiva, Osmann C. C. Oliveira, Victor L. França   +5 more
doaj   +1 more source

A multiple sequential orthogonal least squares algorithm for feature ranking and subset selection [PDF]

, 2005
High-dimensional data analysis involving a large number of variables or features is commonly encountered in multiple regression and multivariate pattern recognition.
Billings, S.A., Wei, H.L.
core  

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Principal components′ analysis of multifocal electroretinogram in retinitis pigmentosa

Indian Journal of Ophthalmology, 2011
Aims : To determine waveforms of multifocal electroretinogram (mfERG) in patients with retinitis pigmentosa (RP) contributing significantly to the overall retinal response by using principal components′ analysis.
Aniruddha Maiti, Mahesh Uparkar, Sundaram Natarajan, Nishikanth Borse, Jaydeep Walinjkar   +4 more
doaj   +1 more source

Improved histogram-based anomaly detector with the extended principal component features [PDF]

, 2019
Sunil Aryal, Arbind Agrahari Baniya, KC Santosh   +2 more
openalex   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Permutation tests to estimate significances on Principal Components Analysis [PDF]

Computational Ecology and Software, 2012
Principal Component Analysis is the most widely used multivariate technique to summarize information in a data collection with many variables. However, for it to be valid and useful the meaningful information must be retained and the noisy information ...
Vasco M. N. C. S. Vieira
doaj