Results 111 to 120 of about 2,294,043 (337)

Incorporating Prior Knowledge of Principal Components in Genomic Prediction

Frontiers in Genetics, 2018
Genomic prediction using a large number of markers is challenging, due to the curse of dimensionality as well as multicollinearity arising from linkage disequilibrium between markers.
Sayed M. Hosseini-Vardanjani, Mohammad M. Shariati, Hossein Moradi Shahrebabak, Mojtaba Tahmoorespur   +3 more
doaj   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Spatial and multivariate analysis of soybean productivity and soil physical-chemical attributes

Revista Brasileira de Engenharia Agrícola e Ambiental
The objective of this study was to evaluate the spatial variability of soybean yield, carbon stock, and soil physical attributes using multivariate and geostatistical techniques.
Ricardo N. Buss, Raimunda A. Silva, Glécio M. Siqueira, Jairo O. R. Leiva, Osmann C. C. Oliveira, Victor L. França   +5 more
doaj   +1 more source

The principal problem with principal components regression

Cogent Mathematics & Statistics, 2019
Principal components regression (PCR) reduces a large number of explanatory variables in a regression model down to a small number of principal components.
Heidi Artigue, Gary Smith
openaire   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

On Estimation of the Noise Variance in High Dimensional Probabilistic Principal Component Analysis [PDF]

, 2015
Damien Passemier, Zhaoyuan Li, Jianfeng Yao   +2 more
openalex   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Mapping discourses through Hierarchical Clustering on Principal Components

Methodological Innovations
This article proposes a methodological framework that combines a Q-concourse questionnaire with Multiple Factor Analysis and Hierarchical Clustering on Principal Components (MFA/HCPC) to derive discourse typologies from large-N survey data. The framework
Francesco Veri
doaj   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Decomposing the Apoptosis Pathway Into Biologically Interpretable Principal Components

Cancer Informatics, 2018
Principal component analysis (PCA) is one of the most common techniques in the analysis of biological data sets, but applying PCA raises 2 challenges. First, one must determine the number of significant principal components (PCs). Second, because each PC
Min Wang, Steven M Kornblau, Kevin R Coombes   +2 more
doaj   +1 more source