Results 61 to 70 of about 469,727 (312)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Augmented approach to desirability function based on principal component analysis

open access: yes, 2022
The desirability function approach is commonly used in industry to tackle multiple response optimization problems. The shortcoming of this approach is that the variability and correlated in each predicted response are ignored.
Thorisingam, Yuvarani   +1 more
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Microstructure and mechanical properties of CoCrNiVAlx multi-principal component alloy

open access: yesJournal of Materials Research and Technology
Multi-principal component alloy has been proved to form disordered solid solution in most cases. However, multi-principal component alloy with single phase solid solution has a few disadvantages in mechanical properties, such as low strength or poor ...
Yuzhi Shi   +8 more
doaj   +1 more source

Robust sparse principal component analysis. [PDF]

open access: yes
A method for principal component analysis is proposed that is sparse and robust at the same time. The sparsity delivers principal components that have loadings on a small number of variables, making them easier to interpret.
Croux, Christophe   +2 more
core  

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

The role of the agent's outside options in principal-agent relationships

open access: yes, 2010
We consider a principal-agent model of adverse selection where, in order to trade with the principal, the agent must undertake a relationship-specific investment which affects his outside option to trade, i.e.
Rasul, I., Sonderegger, S.
core  

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

open access: yesFEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas   +3 more
wiley   +1 more source

Principal matrix solutions and variation of parameters for a Volterra integro-differential equation and its adjoint

open access: yesElectronic Journal of Qualitative Theory of Differential Equations, 2006
We define the principal matrix solution $Z(t,s)$ of the linear Volterra vector integro-differential equation \[ x'(t) = A(t)x(t) + \int_s^t B(t,u)x(u)\,du \] in the same way that it is defined for $x' = A(t)x$ and prove that it is the unique matrix ...
Leigh Becker
doaj   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

open access: yesFEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga   +3 more
wiley   +1 more source

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