Results 61 to 70 of about 469,727 (312)
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Augmented approach to desirability function based on principal component analysis
The desirability function approach is commonly used in industry to tackle multiple response optimization problems. The shortcoming of this approach is that the variability and correlated in each predicted response are ignored.
Thorisingam, Yuvarani +1 more
core +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Microstructure and mechanical properties of CoCrNiVAlx multi-principal component alloy
Multi-principal component alloy has been proved to form disordered solid solution in most cases. However, multi-principal component alloy with single phase solid solution has a few disadvantages in mechanical properties, such as low strength or poor ...
Yuzhi Shi +8 more
doaj +1 more source
Robust sparse principal component analysis. [PDF]
A method for principal component analysis is proposed that is sparse and robust at the same time. The sparsity delivers principal components that have loadings on a small number of variables, making them easier to interpret.
Croux, Christophe +2 more
core
Diversity and complexity in neural organoids
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
The role of the agent's outside options in principal-agent relationships
We consider a principal-agent model of adverse selection where, in order to trade with the principal, the agent must undertake a relationship-specific investment which affects his outside option to trade, i.e.
Rasul, I., Sonderegger, S.
core
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas +3 more
wiley +1 more source
We define the principal matrix solution $Z(t,s)$ of the linear Volterra vector integro-differential equation \[ x'(t) = A(t)x(t) + \int_s^t B(t,u)x(u)\,du \] in the same way that it is defined for $x' = A(t)x$ and prove that it is the unique matrix ...
Leigh Becker
doaj +1 more source
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source

