Results 81 to 90 of about 2,140,628 (292)
Molecular bases of circadian magnesium rhythms across eukaryotes
FEBS Letters, EarlyView.Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley +1 more source
ITERATIVE AGGREGATION METHOD FOR SOLVING PRINCIPAL COMPONENT ANALYSIS PROBLEMS
International Journal for Computational Civil and Structural Engineering, 2017 Motivated by the previously developed multilevel aggregation method for solving structural analysis problems a novel two-level aggregation approach for efficient iterative solution of Principal Component Analysis (PCA) problems is proposed.
Vitaly E. Bulgakov
doaj +1 more source
Hunger In Our Schools 2015 [PDF]
, 2015 In this report educators are revealing the effects that hunger and poverty have on kids, and what they see as the solution. According to the report, 76% of educators say they regularly see students who are struggling with hunger, and attest to the ...
core
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
Constructing a stable complex index of a system’s quality for a series of observations
National Accounting Review, 2019 This paper discusses the solution to the problem of constructing latent complex indexes of a change in a system’s quality for several observations in the absence of training. An analysis of the stability of such a solution is also provided. The algorithm
Tatyana V. Zhgun
doaj +1 more source
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Growth of citrus rootstocks under aluminium stress in hydroponics
Scientia Agricola, 2003 Plants present different degrees of adaptation to aluminium (Al) concentrations in the soil, and the understanding of this characteristic can lead to a viable option for the utilization of acid soils.
Walter Esfrain Pereira +5 more
doaj
International Journal of Concrete Structures and Materials, 2019 While internal and external unbonded tendons are widely utilized in concrete structures, an analytical solution for the increase in unbonded tendon stress at ultimate strength, $$\Delta f_{ps}$$ Δfps , is challenging due to the lack of bond between ...
Eric McKinney +3 more
doaj +1 more source
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source