The protein - only theory and the yeast Saccharomyces cerevisiae: the prions and the propagons
, 2001 Eric Fernandez‐Bellot +1 more
openalex +2 more sources
Selection for Function in Complex Distributed Pathological Systems
Evolutionary Applications, Volume 19, Issue 2, February 2026.ABSTRACT Pathological processes are often conceptualized as localized phenomena anchored in a primary tumor, a focal lesion, or a single organ. However, growing evidence indicates that many diseases persist and progress as complex distributed systems, maintained by interactions among multiple sites.
Frédéric Thomas +9 more
wiley +1 more source
Protein tandem repeats that produce frameshifts can generate new structural states and functions
The FEBS Journal, Volume 293, Issue 3, Page 842-858, February 2026.We explored an alternative protein structure landscape by analyzing amino acid sequences from frameshifted tandem repeats—regions prone to frameshifts. These frameshifts, especially in short repeats, lead to more drastic changes than in non‐repetitive regions, often altering structure, function, localization, and potentially contributing to disease ...
Zarifa Osmanli +8 more
wiley +1 more source
Advancing prion diagnostics: full-length human E200K RT-QuIC substrate facilitates prion detection in tear fluid and improves sensitivity in cerebrospinal fluid. [PDF]
Acta Neuropathol CommunCorreia SDS +12 more
europepmc +1 more source
Structural and functional studies of monomeric and aggregated amyloidogenic forms of prion proteins
, 2002 Thorsten Lührs
openalex +1 more source
Sustainable bioceramics, biopolymers, and composites for bone applications: From bench to production
International Journal of Applied Ceramic Technology, Volume 23, Issue 1, February 2026.Abstract In response to environmental challenges and primary resource scarcity, sustainable approaches that rely on recycling and reusing waste materials are becoming highly valuable and appealing options in modern society. These strategies have started being applied in biomaterials science, too, leading to the advent of new synergies between ...
Bohan Zhang, Francesco Baino
wiley +1 more source
A fixed brain seeded amplification assay to complement neuropathological prion disease diagnosis. [PDF]
J Neuropathol Exp NeurolLewis V +7 more
europepmc +1 more source
Interactions between the prion protein and nucleic acids
, 2018 Peter R. Wills
openalex +1 more source
Neuropathology, Volume 46, Issue 1, February 2026.ABSTRACT Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron disease (MND) characterized by progressive degeneration of both upper and lower motor neurons, along with skeletal muscles innervated by them. The identification of key molecules involved in disease pathology remains crucial for ALS, as no curative treatment is currently available ...
Paloma Martínez‐Alesón +3 more
wiley +1 more source