Neuronal Ndst1 depletion accelerates prion protein clearance and slows neurodegeneration in prion infection [PDF]
, 2023 Patricia Aguilar-Calvo +19 more
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Aggregate, Volume 7, Issue 2, February 2026.Protein aggregation drives diverse degenerative diseases, yet its molecular origins are difficult to predict. SKALE uses interpretable machine learning to link sequence, structure, and dynamics, revealing how local structural weakening triggers aggregation.
Wei Xuan Wilson Loo +7 more
wiley +1 more source
Mouse Prion Protein (PrP) Segment 100 to 104 Regulates Conversion of PrP C to PrP Sc in Prion-Infected Neuroblastoma Cells [PDF]
, 2012 Hideyuki Hara +5 more
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Heat shock protein 10 as a chaperone modulating α‐synuclein amyloid fibril formation
Protein Science, Volume 35, Issue 2, February 2026.Abstract HSP10 is a well‐known human co‐chaperone that interacts with HSP60 to comprise the HSP60/10 chaperonin complex which upholds mitochondrial proteostasis. HSP10 also demonstrates independent roles in binding to misfolded proteins and interacts with several amyloidogenic client proteins.
Johan N. K. Larsson +5 more
wiley +1 more source
Protein Science, Volume 35, Issue 2, February 2026.Abstract Spider silks are proteinaceous fiber materials inspiring material design in various technical and biomedical fields due to their exceptional toughness, which exceeds that of most natural and artificial fibers. Solid‐state nuclear magnetic resonance (NMR) spectroscopy has been used herein to obtain insights into the structure and dynamics of ...
Nina Wehr +6 more
wiley +1 more source
Cellular Prion Protein as a Receptor of Toxic Amyloid-β42 Oligomers Is Important for Alzheimer’s Disease [PDF]
, 2019 Yuan Zhang +5 more
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A complex network perspective on brain disease
Biological Reviews, Volume 101, Issue 1, Page 364-399, February 2026.ABSTRACT If brain anatomy and dynamics have a complex network structure as it has become standard to posit, it is reasonable to assume that such a structure should play a key role not only in brain function but also in brain dysfunction. However, exactly how network structure is implicated in brain damage and whether at least some pathologies can be ...
David Papo, Javier M. Buldú
wiley +1 more source
Review of studies that have used knockout mice to assess normal function of prion protein under immunological or pathophysiological stress [PDF]
, 2014 Takashi Onodera +3 more
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Sustainable bioceramics, biopolymers, and composites for bone applications: From bench to production
International Journal of Applied Ceramic Technology, Volume 23, Issue 1, February 2026.Abstract In response to environmental challenges and primary resource scarcity, sustainable approaches that rely on recycling and reusing waste materials are becoming highly valuable and appealing options in modern society. These strategies have started being applied in biomaterials science, too, leading to the advent of new synergies between ...
Bohan Zhang, Francesco Baino
wiley +1 more source
Biochemical insight into the prion protein family [PDF]
, 2015 Danica Ćirić, Human Rezaei
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