Results 71 to 80 of about 50,704 (271)
Prion propagation can occur in a prokaryote and requires the ClpB chaperone
eLife, 2014 Prions are self-propagating protein aggregates that are characteristically transmissible. In mammals, the PrP protein can form a prion that causes the fatal transmissible spongiform encephalopathies.
Andy H Yuan +3 more
doaj +1 more source
3D‐Printed Protein Models as an Educational Tool in Biochemistry Outreach
Biochemistry and Molecular Biology Education, EarlyView.ABSTRACT The abstract and complex nature of molecular biology often presents significant challenges for students at all levels of study. Traditional teaching methods, such as the use of 2D diagrams, may not fully convey the intricacies of these topics, leading to difficulties in comprehension and engagement. This study aimed to introduce 3D‐printed and
Oliver Osborne +2 more
wiley +1 more source
Porcine prion protein amyloid [PDF]
Prion, 2015 Mammalian prions are composed of misfolded aggregated prion protein (PrP) with amyloid-like features. Prions are zoonotic disease agents that infect a wide variety of mammalian species including humans. Mammals and by-products thereof which are frequently encountered in daily life are most important for human health.
Hammarström, Per, Nyström, Sofie
openaire +2 more sources
Infection Risk From Humans and Animals in the Anatomy Laboratory: A Scoping Review
Clinical Anatomy, EarlyView.ABSTRACT Whole‐body dissection is a cornerstone of anatomy education. During and following the COVID‐19 pandemic, exposure to infectious agents and other risks of dissection were highlighted. To identify potential risks, one must have the data outlining these risks in specific situations.
Margaret A. McNulty, Elizabeth R. Agosto
wiley +1 more source
Cell & Bioscience, 2023 Background Aberrant stress granules (SGs) are emerging as prime suspects in the nucleation of toxic protein aggregates. Understanding the molecular networks linked with aggregation-prone proteins (prion protein, synuclein, and tau) under stressful ...
Neelam Younas +6 more
doaj +1 more source
Catalytic Amyloids: Turning Fibrils Into Biocatalysts
Chemistry – A European Journal, EarlyView.Amyloids, traditionally associated with diseases, have emerged as versatile catalytic scaffolds. From natural amyloid sequences to bioinspired and de novo designs, we highlight strategies to construct catalytic active sites and anchor enzymes onto fibrils, creating versatile nanomaterials with tunable activities. ABSTRACT Amyloids have been regarded as
Alessandra Esposito +3 more
wiley +1 more source
EGR1 Nuclear Condensates Promote Renal Cyst Development in Polycystic Kidney Disease
Exploration, EarlyView.ABSTRACT Autosomal dominant polycystic kidney disease (ADPKD) is marked by aberrant cell proliferation driven by cAMP‐PKA and MAPK signaling pathways. EGR1, a transcription factor directly activated by the above two pathways, is critical in the over‐proliferation of tumor cells, which share similarities with cystic epithelial cells in ADPKD. This study
Chaoqun Ren +15 more
wiley +1 more source
Accumulation of Astrocytic Aquaporin 4 and Aquaporin 1 in Prion Protein Plaques [PDF]
, 2020 Shoko Sadashima +7 more
openalex +1 more source
Plasmonics‐Enhanced Characterization of Cervid PrP (87–114) Fragment Aggregates in Solution
Journal of Biophotonics, EarlyView.Multimodal nanophotonics platform combining plasmon‐enhanced imaging, label‐free SERS, and optical staining reveals new insights into the aggregation of the cervid PrP (87–114) fragment, an amyloidogenic sequence linked to chronic wasting disease susceptibility.
Shinki Midha +4 more
wiley +1 more source
The Journal of Clinical Pharmacology, EarlyView.Abstract Posdinemab, a humanized immunoglobulin G1/κ monoclonal antibody, binds with high affinity to phosphorylated tau protein which is associated with Alzheimer's disease (AD) pathophysiology. Posdinemab reduced tau seeding in murine models and was well tolerated in Phase‐1 clinical studies.
Fangfang Wang +7 more
wiley +1 more source