Results 81 to 90 of about 5,604,422 (355)

Current trends in single‐cell RNA sequencing applications in diabetes mellitus

FEBS Open Bio, EarlyView.
Single‐cell RNA sequencing is a powerful approach to decipher the cellular and molecular landscape at a single‐cell resolution. The rapid development of this technology has led to a wide range of applications, including the detection of cellular and molecular mechanisms and the identification and introduction of novel potential diagnostic and ...
Seyed Sajjad Zadian, Khodakaram Jahanbin, Shekoofeh Nikooei, Marzieh Rostaminejad, Arezoo Rahimi, Pedram Abdizadeh, Behnam Alipoor   +6 more
wiley   +1 more source

Synthesis and structural characterization of a mimetic membrane-anchored prion protein [PDF]

, 2006
During pathogenesis of transmissible spongiform encephalopathies (TSEs) an abnormal form (PrPSc) of the host encoded prion protein (PrPC) accumulates in insoluble fibrils and plaques. The two forms of PrP appear to have identical covalent structures, but
Andrew C. Gill, Ansari AA, Atvinder K. Rullay, Bertozzi CR, Blanch EW, Borchelt D, Caughey B, Caughey B, Caughey B, Caughey BW, Critchley P, David H. Crout, Eberl H, Ferris A, Georges C, Gill AC, Govaerts C, Haire LF, Harris DA, Hornemann S, Ian D. Sylvester, Imanpreet K. Bath, Kazlauskaite J, Kazlauskaite J, Kenyon GL, King SA, Kirby L, Klein TR, Kocienski PJ, Legname G, Matthew R. Hicks, Mui B, Nosjean O, Pan KM, Poss AJ, Safar J, Seddon AM, Shyng SL, Stahl N, Stahl N, Teresa J. T. Pinheiro, Whitesell JK, Wuthrich K, Zahn R, Zhang ZY   +44 more
core   +1 more source

The Potential for Extracellular Vesicles in Nanomedicine: A Review of Recent Advancements and Challenges Ahead

Advanced Biology, EarlyView.
Extracellular vesicles (EVs) play a dual role in diagnostics and therapeutics, offering innovative solutions for treating cancer, cardiovascular, neurodegenerative, and orthopedic diseases. This review highlights EVs’ potential to revolutionize personalized medicine through specific applications in disease detection and treatment.
Farbod Ebrahimi, Anjali Kumari, Samaneh Ghadami, Saqer Al Abdullah, Kristen Dellinger   +4 more
wiley   +1 more source

\u3cem\u3eDe Novo\u3c/em\u3e [PSI\u3csup\u3e+\u3c/sup\u3e] Prion Formation Involves Multiple Pathways to Form Infectious Oligomers [PDF]

, 2017
Prion and other neurodegenerative diseases are associated with misfolded protein assemblies called amyloid. Research has begun to uncover common mechanisms underlying transmission of amyloids, yet how amyloids form in vivo is still unclear. Here, we take
Manogaran, Anita L., Merrill, Stephen J., Obaoye, Joanna O., Paulson, Emily, Sharma, Jaya, Wisniewski, Grett T.   +5 more
core   +1 more source

On the statistical mechanics of prion diseases

, 2001
We simulate a two-dimensional, lattice based, protein-level statistical mechanical model for prion diseases (e.g., Mad Cow disease) with concommitant prion protein misfolding and aggregation.
A. Coghlan, A. Slepoy, C. I. Lasmézas, D. J. Stekel, D. L. Cox, D. O. V. Alonso, F. Pázmándi, H. Rudyk, J. H. Come, J. Masel, J. N. Onuchic, J. S. Griffith, K. Post, M. A. Nowak, M. Beekes, M. Eigen, M. Horiuchi, M. Horiuchi, M. Laurent, R. Demaimay, R. M. Anderson, R. R. P. Singh, R. V. Kulkarni, S. B. Prusiner, T. R. Serio, W. Swietnicki   +25 more
core   +1 more source

Synthetic prions generated in vitro are similar to a newly identified subpopulation of PrPSc from sporadic Creutzfeldt-Jakob disease [PDF]

, 2005
In recent studies, the amyloid form of recombinant prion protein (PrP) encompassing residues 89–230 (rPrP 89-230) produced in vitro induced transmissible prion disease in mice.
Adler, Andrew C. Gill, Barron, Barron, Bartz, Baskakov, Baskakov, Baskakov, Bessen, Bocharova, Caughey, Caughey, Chabry, Chen, Cohen, Deleault, Dickinson, Donne, Fischer, Fraser, Gabizon, Gabus, Gill, Gonzalez-Iglesias, Haire, Hill, Ilia V. Baskakov, Kocisko, Lasmézas, Lawson, Legname, Legname, Leonid Breydo, Manuelidis, McKinley, Notari, Oesch, Olga V. Bocharova, Pan, Paramithiotis, Parchi, Parchi, Pattison, Peretz, Peretz, Prusiner, Prusiner, Prusiner, Prusiner, Riek, Riek, Safar, Santoro, Satoh, Scott, Swietnicki, Tagliavini, Telling, Telling, Tremblay, Vadim V. Salnikov, Wadsworth, Warner, Wille, Wong, Yadavalli, Zou   +66 more
core   +2 more sources

Prion protein interconversions† [PDF]

Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, 2001
The transmissible spongiform encephalopathies (TSEs), or prion diseases, remain mysterious neurodegenerative diseases that involve perturbations in prion protein (PrP) structure. This article summarizes our use ofin vitromodels to describe how PrP is converted to the disease–associated, protease–resistant form.
openaire   +3 more sources

Cryptic Splicing of GAP43 mRNA is a Novel Hallmark of TDP‐43‐Associated ALS and AD

Advanced Science, EarlyView.
TDP‐43 dysfunction disrupts RNA processing, inducing cryptic exon 4a1 inclusion in GAP43 and reducing its protein levels. This aberrant splicing impairs axonal regeneration and contributes to neurodegeneration in ALS and AD. RNA‐seq of patient brains reveals GAP43 downregulation and 4a1 upregulation, identifying cryptic exon 4a1 as a potential ...
Mingming Yang, Qi Wang, Dongkun Kang, Shijia Wang, Yanli Jiang, Jian‐Zhi Wang, Chen Ming, Rong Liu, Jianlan Gu, Xiaochuan Wang   +9 more
wiley   +1 more source

Small critical RNAs in the scrapie agent [PDF]

, 2009
Unconventional infectious agents cause transmissible spongiform encephalopathy (TSE) diseases including scrapie and bovine spongiform encephalopathy (BSE) in animals and Creutzfeldt-Jakob disease in humans. The protein only hypothesis claims that the TSE
Emmanuel Comoy, Jean-Guy Fournier, Jean-Philippe Deslys, Marie-Madeleine Ruchoux, Nicolas Vignier, Pierre Lebon, Sophie Freire, Steve Simoneau   +7 more
core   +1 more source

Genetic Factors Contributing to the Susceptibility of Development of Prion Diseases [PDF]

, 2017
This paper won an honorable mention writing flag award in the research category. Claire Culbertson, writing for Katherine Bruner’s BIO 325L class, “Lab Experience in Genetics”.Bruner, KatherineUndergraduate ...
Culbertson, Claire
core   +1 more source