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Treatment with efavirenz extends survival in a Creutzfeldt-Jakob disease model by regulating brain cholesterol metabolism. [PDF]
JCI InsightAli T +5 more
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Evidence against efficient spontaneous disassembly of prions into small oligomers. [PDF]
J Biol ChemShoup D +6 more
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Evaluation of spatial variation in chronic wasting disease risk with Bayesian Poisson log-Gaussian model. [PDF]
Front Vet SciRaghavan RK +7 more
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Biochemistry (Moscow), 2007
Prions were originally defined as infectious agents of protein nature, which caused neurodegenerative diseases in animals and humans. The prion concept implies that the infectious agent is a protein in special conformation that can be transmitted to the normal molecules of the same protein through protein-protein interactions.
I S, Shkundina, M D, Ter-Avanesyan
openaire +2 more sources
Prions were originally defined as infectious agents of protein nature, which caused neurodegenerative diseases in animals and humans. The prion concept implies that the infectious agent is a protein in special conformation that can be transmitted to the normal molecules of the same protein through protein-protein interactions.
I S, Shkundina, M D, Ter-Avanesyan
openaire +2 more sources
Current Biology, 1992
There have been remarkably rapid advances in the understanding of prion diseases over the past year. The controversial notion that the transmissible agent may be an abnormal isoform of a host-encoded protein, the prion protein, is now gaining wide acceptance.
J, Collinge, M S, Palmer
openaire +2 more sources
There have been remarkably rapid advances in the understanding of prion diseases over the past year. The controversial notion that the transmissible agent may be an abnormal isoform of a host-encoded protein, the prion protein, is now gaining wide acceptance.
J, Collinge, M S, Palmer
openaire +2 more sources
Prions and the prion disorders
Mammalian Genome, 1998One of us remembers sitting in a high school biology class in 1977 being taught about scrapie, a naturally occurring disorder of sheep. The teacher had no particular interest in agriculture, but was pointing out some peculiar characteristics of this disease as a biological curiosity on a wet Friday afternoon.
E, Fisher, G, Telling, J, Collinge
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