Results 51 to 60 of about 41,826 (310)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Cogent EngineeringManufacturing industries implement lean production tools to improve their production efficiencies. Improving production efficiency is vital in the apparel industry because product cycles and lead times are getting shorter and shorter. The purpose of this
Berihun Bizuneh, Rahmet Omer
doaj +1 more source
Exploratory Research in Clinical and Social Pharmacy, 2023 Background: The number and complexity of patients being admitted to hospitals is rising and some patients may not receive a full clinical pharmacy review or be reviewed as regularly as needed during their inpatient stay.
Rebecca Clarke +3 more
doaj +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Working Memory Prioritisation with Tactile Stimuli
, 2021 This experiment examines whether working memory prioritisation effects occur within tactile sequence order memory. Specifically, if there is improved recall for prioritised position and therefore a spike in the serial position curve.
Richard Allen, Andrew Johnson, Daisy Roe
core +1 more source
Military scienceThe modern character of military operations is characterised by an increase in spatial scale, high maneuverability, rapid changes in the operational environment, the need for timely and well-founded decision-making, and the integration of a large number ...
Валерій Залужний
doaj +1 more source
How can we improve priority-setting for investments in health research? A case study of tuberculosis
Health Research Policy and Systems, 2019 Background Although enhanced priority-setting for investments in health research for development is essential to tackling inequalities in global health, there is a lack of consensus on an optimal priority-setting process. In light of the current surge in
Mishal S. Khan +3 more
doaj +1 more source
FEBS Letters, EarlyView.The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson +6 more
wiley +1 more source
Frontiers in Environmental ScienceThe recently revised European Urban Wastewater Treatment Directive (Directive (EU) 2024/3019) requires Member States to identify where organic micropollutants (OMPs) pose risks and to prioritize wastewater treatment plants (WWTPs) for advanced ...
L. Önnby, C. Baresel, E. Björklund
doaj +1 more source
Rapid assessment of sacred groves: a biodiversity assessment tool for ground level practitioners
Journal of Threatened Taxa, 2018 Sacred groves in the Western Ghats are culturally preserved patches of forests that are rich in diversity owing to protection by several generations of local people, providing excellent examples of community based conservation.
Shivam Trivedi +2 more
doaj +1 more source