Results 51 to 60 of about 57,041 (306)
Frontiers in Environmental ScienceThe recently revised European Urban Wastewater Treatment Directive (Directive (EU) 2024/3019) requires Member States to identify where organic micropollutants (OMPs) pose risks and to prioritize wastewater treatment plants (WWTPs) for advanced ...
L. Önnby, C. Baresel, E. Björklund
doaj +1 more source
How can we improve priority-setting for investments in health research? A case study of tuberculosis
Health Research Policy and Systems, 2019 Background Although enhanced priority-setting for investments in health research for development is essential to tackling inequalities in global health, there is a lack of consensus on an optimal priority-setting process. In light of the current surge in
Mishal S. Khan +3 more
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From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Rapid assessment of sacred groves: a biodiversity assessment tool for ground level practitioners
Journal of Threatened Taxa, 2018 Sacred groves in the Western Ghats are culturally preserved patches of forests that are rich in diversity owing to protection by several generations of local people, providing excellent examples of community based conservation.
Shivam Trivedi +2 more
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Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Evidence-Informed Surgical Systems Strengthening with Meaningful Stakeholder Involvement in Low-Resource Settings: A Response to Recent Commentaries [PDF]
International Journal of Health Policy and ManagementEvidence-Informed Surgical Systems Strengthening with Meaningful Stakeholder Involvement in Low-Resource Settings: A Response to Recent ...
Leon Bijlmakers +4 more
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A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
Prioritisation / query interface (screenshot).
, 2013 This figure shows the query interface of GeneDistiller for the prioritisation example for epilepsy described in the text. The interface is divided into different sections in which the parameters describing a similar aspect of the gene-specific data are ...
Markus Schuelke (223245) +2 more
core +1 more source
The ubiquitin system in normal and infected germinal center B cells
FEBS Letters, EarlyView.The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis +2 more
wiley +1 more source