Results 71 to 80 of about 57,041 (306)

A role for eIF5A in translational control of stress‐inducible proteins in multiple myeloma cell lines

Molecular Oncology, EarlyView.
Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both, Ingrid A. M. Derks, Raphaël Vanleyssem, Marine Leclercq, Najla El Hachem, Pierre Close, Eric Eldering, Marco Vincent Haselager   +7 more
wiley   +1 more source

Assessment and prioritisation of pathways

, 2018
Slide of the Euphresco project 2016-G-228 'Assessment and prioritisation of pathways'Project funded through the Euphresco ...
Crowe Andrew (8208543), Crowe Andrew
core   +1 more source

Editorial: Identification of phenotypically important genomic variants

Frontiers in Bioinformatics, 2023
Elizabeth A. Heron, Giorgio Valle, Anna Bernasconi   +2 more
doaj   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

A User-Driven Prioritisation Process implementation and optimisation for ATFM hotspot resolution [PDF]

The current and forecast air traffic levels lead to demand-capacity imbalances, which are dealt with by delaying flights through the allocation of air traffic flow management (ATFM) slots.
Pilon, Nadine, Gurtner, Gérald, Gasparin, Andrea, Castelli, Lorenzo, Bolić, Tatjana, Gurtner, G., Bolic, T., Gasparin, A., Castelli, L., Pilon, N.   +9 more
core   +1 more source

The effect of working memory prioritisation on the Hebb repetition effect

, 2023
The present study will investigate whether Hebb learning will be affected by Working Memory Prioritisation effects (henceforth referred to as prioritisation effects).
Andrew Johnson, Daisy Roe
core   +1 more source

Using maternal sepsis patient journeys to map and prioritise barriers to quality maternal healthcare in Malawi: a multidisciplinary stakeholder consultation workshop

Global Health Action
Background Malawi has made progress in improving access to maternity care services, shifting the focus to quality of care as an essential determinant of maternal health outcomes. However, no effective mechanisms exist to use patients’ experiences of care
Yamikani Chimwaza, Dalisto Ndaferankhande, Leonard Mndala, Chifundo Ndamala, Emily Lifa, Mercy Machilika, Esther Mwagomba, Bernard Dossie, Meliya Kwelepeta, Bertha Maseko, David Lissauer, Maria Lisa Odland   +11 more
doaj   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Spatial prioritisation of management for biodiversity conservation across the EU

, 2022
The last report on the State of the Nature in the European Union (EU), a periodic monitoring exercise at continental scale, shows that biodiversity continues to decline, despite the efforts done in the last decades. Urgent action is, therefore, needed to
Hermoso, V, Álvarez-Miranda, E, Salgado-Rojas, J, Lanzas, M   +3 more
core   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source