Results 61 to 70 of about 57,041 (306)

Space junk: Behavioural economics and the prioritisation of solutions

open access: yes, 2021
The use and exploration of outer space is, according to the Outer Space Treaty (OST), to be carried out for the benefit and interest of all parties. Outer space is critically important to the defence and national security interests of many nations, none ...
Phillips, Peter J., Pohl, Gabriela
core   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

open access: yesFEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana   +3 more
wiley   +1 more source

NASA Turbofan Anomaly Prioritisation

open access: yes, 2022
Companion to In-flight Novelty Detection with Convolutional Neural Networks paper with the implementation of anomaly prioritisation system.  Dataset available at https://www.kaggle.com/datasets/behrad3d/nasa-cmaps Original dataset provided by the ...
Felipe Montana Gonzalez (6434531)   +1 more
core   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

open access: yesMolecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach   +9 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

open access: yesMolecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang   +9 more
wiley   +1 more source

Prioritisation Effects in Tactile Working Memory under Concurrent Articulation

open access: yes, 2022
Recently, prioritisation effects have been shown to occur in the tactile modality. It is possible that the recently obtained tactile prioritisation effects merely reflect verbal prioritisation following verbal recoding of the tactile stimulations. We are
Richard Allen, Andrew Johnson, Daisy Roe
core   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

open access: yesMolecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche   +10 more
wiley   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani   +9 more
wiley   +1 more source

The Impact of Different Prioritisation Policies on Waiting Times: A Comparative Analysis of Norway and Scotland [PDF]

open access: yes
We compare the distributional consequences of two different waiting times initiatives. The primary focus of Scotland’s recent waiting time reforms has been on reducing maximum waiting times through the imposition of high profile national targets.
Askildsen, Jan Erik   +4 more
core  

Perceptual prioritisation of self-associated voices

open access: yes, 2021
Information associated with the self is prioritised relative to information associated with others and is therefore processed more quickly and accurately.
Carolyn McGettigan   +3 more
core   +1 more source

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