Results 151 to 160 of about 260,325 (267)

Midwifery Research Priorities in Saudi Arabia: A Priority-Setting Partnership Approach. [PDF]

Int J Womens Health
Abdulghani N.
europepmc   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Research priorities for back pain: Results from an adapted James Lind Alliance priority setting partnership. [PDF]

PLoS One
Killingmo RM, Bånerud IF, Lunestad AT, Selven AMS, Steen E, Eikrem AI, Ljøstad I, Skogstad T, Storheim K, Martinsen A.   +9 more
europepmc   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Identifying research priorities in adult intensive care in the United Kingdom: Results from a James Lind Alliance priority setting partnership. [PDF]

J Intensive Care Soc
Rose L, Wallace S, Abdillahi A, Borysik B, Bruce J, Burgess S, Crawford A, Gronlund T, Jarvis J, Jones J, Lacorcia L, Leighton S, Linstead G, Mach M, Negus-Fancey M, Newton-Smith S, Norman S, Ostermann M, Peng Y, Ramsay P, Sapsford D, Sharkey B, Tarpey M, Wade D, Watson J, Summers C.   +25 more
europepmc   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Top 10 priorities for midwifery practice and maternity care research in the UK: findings from the James Lind Alliance priority setting partnership. [PDF]

BMJ Open
Field J, Webb S, Cunningham J.
europepmc   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Patient partnership in primary health care systems of the future: a structured priority setting exercise. [PDF]

Res Involv Engagem
Ganann R, MacNeil M, Tagami A, Boyle J, Cruickshank C, Alshaikhahmed A, Barker J, Stans J, Chisholm A, Akbari G, Beleno R, Huang M, Leid C, Ramsden VR.   +13 more
europepmc   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source