Results 191 to 200 of about 260,325 (267)

Diabetes Priorities Questionnaire (DPQ): a codesigned preclinic priority setting tool to enable patient-centred care for people with type 2 diabetes. [PDF]

BMJ Open
Ravi S, Ayre J, Serrano J, Maberly G, McCaffery K, Bonner C.   +5 more
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Reducing the burden of osteoarthritis in Australia: A 2024-2025 research priority-setting study. [PDF]

Osteoarthr Cartil Open
Bennell KL, Pardo JJ, Hinman RS, Little CB, Blaker CL, Bowden JL, Lawford BJ, Metcalf B, Bidgood N, Yii C, Stratulate S, Hunter DJ.   +11 more
europepmc   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Priority Setting in the Context of Planetary Healthcare. [PDF]

Appl Health Econ Health Policy
Apantaku GO, Kapiriri L, Norheim OF, de Azevedo ICC, Kim D, Hensher M, Ananthapavan J, Bhopal A, MacNeill AJ, Sherman JD, Mitton C.   +10 more
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Patient-Oriented Priorities for Pediatric Erythromelalgia: A Priority-Setting Process. [PDF]

Children (Basel)
Ocay DD, Halpin M, Ford E, Keighley K, Keighley N, Ramsay N, Ramsay T, Sheridan CM, Sheridan SM, Tice KR, De Ranieri D, Tham SW, Brownstein CA, Clinch J, Davis DM, Donado C, D'Souza G, Kattail D, Lobo K, Ravetti D, Sandroni P, Stinson JN, Walco GA, Walker SM, Yu TW, Berde CB.   +25 more
europepmc   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

The Ethical Basis of Severity as a Priority Setting Criterion in Healthcare-Egalitarian or Prioritarian? [PDF]

J Bioeth Inq
Juth N, Gustavsson E, Sandman L.
europepmc   +1 more source