Results 201 to 210 of about 260,325 (267)

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region

FEBS Open Bio, EarlyView.
Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson, Anja H. Schiemann, Evelyn Sattlegger   +2 more
wiley   +1 more source

Enhancing System Empathy Within a UK Emergency Department: A Feasibility Interprofessional Priority Setting Exercise. [PDF]

J Eval Clin Pract
Howick J, Ward A, Grantham C, Bennett-Weston A.   +3 more
europepmc   +1 more source

Priority setting for supportive care research in children and young people with cancer. [PDF]

Support Care Cancer
Morgan JE, Evans C, Phillips RS.
europepmc   +1 more source

Towards patient-centered research in pregnancy-associated breast cancer: creating a science agenda through a priority-setting-partnership. [PDF]

Breast
Bakhuis CFJ, Koning AS, Suelmann BBM, Baas IO, Nijkamp JW, Coutinho-Steentjes K, Gilsing-Doreleijers PA, Guerra M, Hoppentocht AGH, Kaashoek-de Jong E, Nijholt N, van der Wielen R, Ruiter JE, Linn SC, Preković S, Van Diest PJ, van der Wall E, van Dooijeweert C.   +17 more
europepmc   +1 more source

Priority-Setting and Values: A Qualitative Study of the Danish Medicines Council. [PDF]

J Bioeth Inq
Dorf AC, Albertsen A, Nielsen L.
europepmc   +1 more source

The ARISE (Autism Research Initiatives for Suicidality and Empowerment) Project: A study protocol for a modified James Lind Alliance priority-setting process determining research priorities for suicidality in autistic youth. [PDF]

BMJ Open
Andreasen S, Birnie K, Lunsky Y, McMorris CA.   +3 more
europepmc   +1 more source

Low use of data analytics for health sector priority-setting in Ghana: A case for strengthening analytical capacity. [PDF]

PLOS Glob Public Health
Dankwa EA, Wambura C, Al Mubarokah M, Matta CJ, Gado B, Komesuor J, Savage Ii JV, Makido A, Baiden F, Noor AM.   +9 more
europepmc   +1 more source