Results 221 to 230 of about 262,059 (354)

Approaches for community intervention and research priority setting to reduce health inequalities: a scoping review. [PDF]

J Public Health (Oxf)
Shuttleworth CE, Birch JM, Bell L, Ogunyemi M, Ley CD, Lully H, Wilcox J, Grant R, Whitehouse J, Dracup N, Staniszewska S, Chen YF.   +11 more
europepmc   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Research priorities for stillbirth in Australia: outcomes of a national priority setting partnership. [PDF]

BMC Pregnancy Childbirth
Tindal K, Boyle F, Andrews C, Astell C, Yelland J, McIntyre S, Jenkinson B, Seeho S, Davies-Tuck M, Stuart-Butler D, Middleton P, Ellwood D, Gordon A, Flenady V.   +13 more
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Reducing the burden of osteoarthritis in Australia: A 2024-2025 research priority-setting study. [PDF]

Osteoarthr Cartil Open
Bennell KL, Pardo JJ, Hinman RS, Little CB, Blaker CL, Bowden JL, Lawford BJ, Metcalf B, Bidgood N, Yii C, Stratulate S, Hunter DJ.   +11 more
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Patient-Oriented Priorities for Pediatric Erythromelalgia: A Priority-Setting Process. [PDF]

Children (Basel)
Ocay DD, Halpin M, Ford E, Keighley K, Keighley N, Ramsay N, Ramsay T, Sheridan CM, Sheridan SM, Tice KR, De Ranieri D, Tham SW, Brownstein CA, Clinch J, Davis DM, Donado C, D'Souza G, Kattail D, Lobo K, Ravetti D, Sandroni P, Stinson JN, Walco GA, Walker SM, Yu TW, Berde CB.   +25 more
europepmc   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Enhancing System Empathy Within a UK Emergency Department: A Feasibility Interprofessional Priority Setting Exercise. [PDF]

J Eval Clin Pract
Howick J, Ward A, Grantham C, Bennett-Weston A.   +3 more
europepmc   +1 more source