Results 221 to 230 of about 5,438,748 (355)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Reducing the burden of osteoarthritis in Australia: A 2024-2025 research priority-setting study. [PDF]

Osteoarthr Cartil Open
Bennell KL, Pardo JJ, Hinman RS, Little CB, Blaker CL, Bowden JL, Lawford BJ, Metcalf B, Bidgood N, Yii C, Stratulate S, Hunter DJ.   +11 more
europepmc   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Enhancing System Empathy Within a UK Emergency Department: A Feasibility Interprofessional Priority Setting Exercise. [PDF]

J Eval Clin Pract
Howick J, Ward A, Grantham C, Bennett-Weston A.   +3 more
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

87:poster Public participation: healthcare rationing in the newspaper media

BMJ Global Health, 2022
Ole Frithjof Norheim, Bjarne Robberstad, Audun Brendbekken   +2 more
doaj   +1 more source

Patient-Oriented Priorities for Pediatric Erythromelalgia: A Priority-Setting Process. [PDF]

Children (Basel)
Ocay DD, Halpin M, Ford E, Keighley K, Keighley N, Ramsay N, Ramsay T, Sheridan CM, Sheridan SM, Tice KR, De Ranieri D, Tham SW, Brownstein CA, Clinch J, Davis DM, Donado C, D'Souza G, Kattail D, Lobo K, Ravetti D, Sandroni P, Stinson JN, Walco GA, Walker SM, Yu TW, Berde CB.   +25 more
europepmc   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

What are the top 10 global research priorities for perianal Crohn's disease? The Global Perianal Crohn's Disease Priority Setting Partnership. [PDF]

J Crohns Colitis
Pelly T, Anand E, Gower J, Mannick S, Hough T, Markham S, Sebastian S, Buskens C, Mccurdy JD, Deepak P, Radmard AR, Stoker J, Lung P, Kotze PG, Younge L, Robinson D, Joshi S, Shakweh E, Hanna L, Singh H, Khan Y, Nightingale K, Powell N, Tozer P, Hart A, PSP Collaborators.   +25 more
europepmc   +1 more source