Results 81 to 90 of about 1,556,687 (280)
International Journal of COPD, 2021 Toshihiko Kaise,1 Eishin Sakihara,2 Kentaro Tamaki,3 Hiroaki Miyata,4 Norimichi Hirahara,4 Oksana Kirichek,5 Ryosuke Tawara,1 Shoko Akiyama,1 Masayuki Katsumata,1 Mei Haruya,6 Takeo Ishii,7 Edgar P Simard,8 Bruce E Miller,8 Ruth Tal-Singer8 1Japan ...
Kaise T +13 more
doaj
Auditory perception of the thickness of plates [PDF]
JASA Express LettersThis study focuses on the auditory perception of plate thickness and investigates acoustic cues that evoke thickness in the context of sound synthesis. Three hypotheses are proposed and tested through a listening test, examining the influence of damping,
Samuel Poirot +3 more
doaj +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
The prism manifold realization problem II [PDF]
, 2017 We continue our study of the realization problem for prism manifolds. Every prism manifold can be parametrized by a pair of relatively prime integers $p>1$ and $q$.
Ballinger, William +3 more
core +1 more source
Identifying combinations of tetrahedra into hexahedra: a vertex based strategy
, 2018 Indirect hex-dominant meshing methods rely on the detection of adjacent tetrahedra an algorithm that performs this identification and builds the set of all possible combinations of tetrahedral elements of an input mesh T into hexahedra, prisms, or ...
Johnen, Amaury +3 more
core +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Just below the surface: developing knowledge management systems using the paradigm of the noetic prism [PDF]
, 2004 In this paper we examine how the principles embodied in the paradigm of the noetic prism can illuminate the construction of knowledge management systems.
Gammack, J., Hobbs, V.J., Pigott, D.
core +1 more source
Inference with Constrained Hidden Markov Models in PRISM
, 2010 A Hidden Markov Model (HMM) is a common statistical model which is widely used for analysis of biological sequence data and other sequential phenomena.
Chang +12 more
core +1 more source
The Lancet Public Health, 2019 Summary: Background: The vast majority of individuals with familial hypercholesterolaemia in the general population remain unidentified worldwide. Recognising patients most likely to have the condition, to enable targeted specialist assessment and ...
Stephen Weng, PhD +3 more
doaj +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source