Results 61 to 70 of about 1,116,380 (291)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Use of Respiratory Support in the Biphase Ventilation Airway Mode in the Newborn

Общая реаниматология, 2006
Biphasic positive airway pressure (BIPAP) (also known as DuoPAP, BiLevel, BiVent, PCV+, SPAP) is a mode of ventilation with cycling variations between two continuous positive airway pressure levels.
S. N. Koval, A. Ye. Kulagin
doaj   +1 more source

Evaluation of Pediatric Intensive Care Patients and Factors Affecting Mortality

Journal of Pediatric Emergency and Intensive Care Medicine, 2021
Introduction:Pediatric intensive care units (PICUs) are the places where there are advanced technologic substructures for critically ill patients to survive, an important teamwork is displayed, and remarkable knowledge and experience are required.The aim
Merve Havan, Serhan Özcan, Oktay Perk, Emrah Gün, Tanıl Kendirli   +4 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Evaluation of the Performance of PRISM III and PIM II Scores in a Tertiary Pediatric Intensive Care Unit

Journal of Pediatric Emergency and Intensive Care Medicine, 2023
Introduction: The most commonly used scoring systems for the assessment of predicted mortality (PDR) in the pediatric intensive care unit are the “pediatric risk of mortality” (PRISM) and the “pediatric index of mortality” (PIM) scores.
Büşra Uzunay Gündoğan, Oğuz Dursun, Nazan Ülgen Tekerek, Levent Dönmez   +3 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Retrospective analysis of the risk factors for developing phacomorphic glaucoma

Indian Journal of Ophthalmology, 2011
Aim : To determine the risk factors for developing phacomorphic glaucoma in eyes with mature cataracts. Materials and Methods : This is a case-control study comprising of 90 eyes with phacomorphic glaucoma and 90 age- and sex-matched control eyes with ...
Jacky W Y Lee, Jimmy S M Lai, Robert F Lam, Billy K T Wong, Doris W F Yick, Raymond K K Tse   +5 more
doaj   +1 more source

The application of the right rectangular prism in the process determining the value of terrain correction [PDF]

Tehnika, 2015
The effects of topographic masses on gravity were determined for the territory of Serbia by using the digital terrain model with resolution of 1 arch second in both directions. For the effect of distant masses, i.e.
Odalović Oleg R., Grekulović Sanja M., Vasiljević Ivana M.   +2 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

smartlobo/PRISM: Polyhedral Reinforced Interior Shell Method

, 2022
The PRISM model can accurately capture non-spherical particle characteristics, with the flexibility to customize the material properties to simulate heterogeneous and anisotropic characteristics.
smartlobo
core   +1 more source