Results 41 to 50 of about 178,592 (262)
Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis
FEBS Letters, EarlyView.This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng +8 more
wiley +1 more source
Acta Crystallographica Section E: Crystallographic Communications, 2023 The formation of the two title compounds, Na3[Sm(DPA)3]·14H2O trisodium tris(pyridine-2,6-dicarboxylato-κ3O2,N,O6)samarate(III) tetradecahydrate, Na3[Sm(C7H3NO4)3]·14H2O, and catena-poly[[[diaqua(6-carboxypyridine-2-carboxylato-κ3O2,N,O6)samarium(III)]-μ-
Sabina Svava Mortensen +1 more
doaj +1 more source
Communication Processes in Social Systems Through the Prism of the Paradigm of Complexity
Izvestiya of Saratov University. New Series. Series: Philosophy. Psychology. Pedagogy, 2020 This article is focused on the results of the study of social systems based on the principles of the Complexity Paradigm.Our research task is focused on the analysis of communication processes in social systems. Our objective is to study their way of functioning of the parameters which we find in “a human” type of social systems.
openaire +1 more source
Europeanisation through the prism of regime complexity: the case of French aid [PDF]
European Politics and Society, 2015 The challenge of isolating the impact of Europeanisation is an arduous one, which explains why analysts have preferred complex rather than parsimonious explanations of this phenomenon. Given this predilection among scholars, it is surprising that the concept of regime complexity has not been meaningfully applied in the Europeanisation literature.
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Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
The Arctic with Chinese Characteristics
Арктика и Север, 2023 Year by year, the Arctic is becoming an increasingly complex geopolitical and geoeconomic epicenter of interaction and simultaneous confrontation between Arctic and non-Arctic actors in international relations.
Ramir Kh. Akimov
doaj +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Yuanzineng kexue jishu, 2022 To further understand the complexation of An(Ⅲ) and Ln(Ⅲ) with tetraalkyl diglycolamides (TRDGA), the complexation of Pr(Ⅲ) with water-insoluble N, N′-dimethyl-N,N′-dioctyl-diglycolamide (DMDODGA, L) and water-soluble tetramethyl-diglycolamide (TMDGA, L′)
YANG Suliang;ZHANG Yan;LIU Qian;KOU Fei;MA Siqi;TIAN Guoxin
doaj
First magmatism in the New England Batholith, Australia: forearc and arc–back-arc components in the Bakers Creek Suite gabbros [PDF]
Solid Earth, 2017 The New England Orogen, eastern Australia, was established as an outboard extension of the Lachlan Orogen through the migration of magmatism into forearc basin and accretionary prism sediments.
S. J. McKibbin +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source