Results 61 to 70 of about 178,592 (262)

EFFECT OF EDEM1 OVEREXPRESSION ON THE GENERATION AND ASSEMBLY OF MAJOR HISTOCOMPATIBILITY COMPLEXES [PDF]

Romanian Journal of Rheumatology, 2016
Background. A better understanding of the role of endoplasmic reticulum degradation-enhancing alpha-mannosidase – like protein 1 (EDEM1) in endoplasmic reticulum associated degradation (ERAD) may open new therapeutic approaches in autoimmune diseases ...
Alexandra Circiumaru, Gabriela Chiritoiu, Livia Sima, Mihai Bojinca, Stefana Petrescu   +4 more
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Complex Regional Pain Syndrome (CRPS) view through the prism of today

Psychosomatic Medicine and General Practice, 2023
These graphic materials are a poster presentation for the III Congress with international participation "PSYCHOSOMATIC MEDICINE OF THE XXI CENTURY: REALITIES AND PERSPECTIVES". Which took place on November 4-6, 2022 in Kyiv on the Mediamed portal.
openaire   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Preparation, spectroscopic studies and X-ray structure of homobinuclear lanthanide(III) complexes derived from 2,6-diformyl-4-chlorophénol-bis-(2’-hydroxy-benzoylhydrazone)

Bulletin of the Chemical Society of Ethiopia, 2006
Reaction of the 2,6-diformyl-4-chlorophenol-bis-(2'-hydroxy-benzoylhydrazone) with Ln(NO3)3.nH2O (n = 5 or 6 and Ln = Y, La, Ce, Pr, Nd, Sm, Gd, Dy, Er and Yb) produces homobinuclear complexes.
Pepe Marcel Haba, Farba Bouyagui Tamboura, Ousmane Diouf, Mohamed Gaye, Abdou Salam Sall, Cheick Abdoul Baldé, Carla Slebodnick   +6 more
doaj  

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

THE INTRINSIC EXPLANATORY VALUE OF SOCIAL CONSTRUCTIVISM IN INTERNATIONAL RELATIONS THEORY

Сравнительная политика, 2016
Why has constructivism emerged as an important force in the field of international relations and politics in the end of the 20th century? Why constructivism and not any other theoretical approach? The constructivist perspective of international relations
Ts. V. Karkalanov
doaj   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

Recent geodynamics, active faults and earthquake focal mechanisms of the zone of pseudosubduction interaction between the Northern and Southern Caucasus microplates in the southern slope of the Greater Caucasus (Azerbaijan)

Геодинамика и тектонофизика, 2018
Our study was focused on the active tectonics of the southern slope of the Greater Caucasus within Azerbaijan. The study area is the zone of under-thrusting (pseudosubduction) interaction between Southern and Northern Caucasus continental microplates ...
T. N. Kangarli, F. A. Kadirov, G. J. Yetirmishli, F. A. Aliyev, S. E. Kazimova, А. M. Aliyev, R. T. Safarov, U. G. Vahabov   +7 more
doaj   +1 more source