Results 131 to 140 of about 195,399 (280)

A Non‐Mitophagy Activity of BNIP3L/NIX in Amygdala Glutamatergic Neurons is Essential for Contextual Fear Memory Formation

Advanced Science, EarlyView.
Contextual fear conditioning induces BNIP3L‐dependent mitochondrial fission in glutamatergic neurons of the BLA, independently of mitophagy. Loss of BNIP3L elevates Drp1Ser637 phosphorylation, thereby suppressing mitochondrial fission, compromising ATP production, and attenuating excitatory synaptic transmission.
Xingxian Zhang, Xinlei Mo, Xinyu Zhou, Xiaoliang Liu, Guizhi Li, Songhui Hu, Yangyang Lu, Chenze Zhu, Jinxi Feng, Zhitong Chen, Weiwei Hu, Yihui Cui, Zhong Chen, Xiangnan Zhang   +13 more
wiley   +1 more source

Distinct Immunomodulatory Strategies Guide Mesenchymal Stromal/Stem Cell‐Mediated Bone Regeneration

Advanced Science, EarlyView.
Bone regeneration by mesenchymal stem cells is strongly influenced by immune signals. This study shows that priming stem cells with regulatory immune cells or an inflammation‐resolving lipid molecule enhances bone formation through distinct immune pathways.
Salwa Suliman, Carla Alvarez Rivas, Aashish Srivastava, Nora Marek, Kamal Mustafa, Alpdogan Kantarci   +5 more
wiley   +1 more source

Intelligent Monitoring System with Privacy Preservation Based on Edge AI. [PDF]

Micromachines (Basel), 2023
Kim S, Park J, Jeong Y, Lee SE.
europepmc   +1 more source

A NeuroD1 AAV‐Based Gene Therapy for Functional Brain Repair in Alzheimer's Disease‐Like Non‐Human Primate Model

Advanced Science, EarlyView.
This study tests NeuroD1 AAV‐based gene therapy in a non‐human primate Alzheimer's disease model. The therapy prevents neuronal damage, inhibits hippocampal atrophy, and reduces neuroinflammation. It also repairs vascular and blood‐brain barrier damage, restores cerebrospinal fluid biomarkers, enhances hippocampal glucose metabolism, and improves ...
Zhouquan Jiang, Yongpeng Qin, Bin Luo, Fan Bai, Jiangyue Liu, Long Ma, Shu He, Rongjie Chen, Yuchen Wang, Shanggong Liu, Ying Sun, Yi Chen, Shuo Zhang, Jiaqi Liang, Feng Liao, Huiyi Wei, Junjie Wei, Lu Wang, Hao Xu, Zheng Wu, Gong Chen, Wenliang Lei   +21 more
wiley   +1 more source

Federated learning with differential privacy for breast cancer diagnosis enabling secure data sharing and model integrity

Scientific Reports
In the digital age, privacy preservation is of paramount importance while processing health-related sensitive information. This paper explores the integration of Federated Learning (FL) and Differential Privacy (DP) for breast cancer detection ...
Shubhi Shukla, Suraksha Rajkumar, Aditi Sinha, Mohamed Esha, Konguvel Elango, Vidhya Sampath   +5 more
doaj   +1 more source

AML‐Targeted Metal‐Polyphenol Nanoplatform Induces Ferroptosis‐ICD Cascade for Antitumor Immunity Boosting

Advanced Science, EarlyView.
Schematic illustration of the synthesis protocol for Fe‐SH@Fn, an AML‐targeted nanoplatform engineered to co‐deliver shikonin (SH) and Fe3+, synergistically boosting antitumor immunity via ferroptosis induction and immunogenic cell death (ICD). ABSTRACT Acute myeloid leukemia (AML) remains a therapeutic challenge due to its low immunogenicity and ...
Shangqin Yang, Jingxuan Wang, Kerong Tu, Xiaobing Huang, Liangliang Lv, Mingjie Peng, Qiqi Xu, Hongmei Liu, Qiang Sun, Lulu Cai   +9 more
wiley   +1 more source

Interoperable IoMT Approach for Remote Diagnosis with Privacy-Preservation Perspective in Edge Systems. [PDF]

Sensors (Basel), 2023
Subramaniam EVD, Srinivasan K, Qaisar SM, Pławiak P.   +3 more
europepmc   +1 more source

Engineered Interpenetrating MXene Networks in Aramid Layered Films for Antioxidant and Broadband Electromagnetic Interference Shielding

Advanced Science, EarlyView.
This study introduces an innovative interpenetrating layered structure, comprising alternating aramid nanofiber (ANF) layers and MXene layers, fabricated through a directional freeze–thaw intercalation–gel‐film formation strategy. Unlike traditional homogeneous layered films, this unique layered structure features mutually embedded conductive and ...
Hongli Cheng, Gaojie Han, Congqi Liu, Yang Zhou, Yiming Wang, Bing Zhou, Yuezhan Feng, Chuntai Liu, Hao‐Bin Zhang, Changyu Shen   +9 more
wiley   +1 more source

Loss of VMP1 Impairs Tight Junction Recycling and Aggravates Intestinal Barrier Dysfunction in Inflammatory Bowel Disease

Advanced Science, EarlyView.
This study identifies vacuole membrane protein 1 (VMP1) as a critical regulator of intestinal epithelial barrier homeostasis. VMP1 facilitates the recruitment of CORO1C to late endosomes, supporting Retromer‐mediated recycling of the tight junction protein Occludin.
Jiawei Zhao, Jianjun Zou, Chen Zhou, Yingui Wang, Yiman Liu, Yanqing Zhou, Yuxiang Wang, Xinyu Zhang, Huishu Yang, Hongjie Yin, Dongsheng Bai, Yue Zhao, Na Lu   +12 more
wiley   +1 more source

Privacy Preservation in Smart Meters: Current Status, Challenges and Future Directions. [PDF]

Sensors (Basel), 2023
Kua J, Hossain MB, Natgunanathan I, Xiang Y.   +3 more
europepmc   +1 more source