Drug–drug interaction profile of ritlecitinib as perpetrator and victim through cytochrome P450
Aims To assess the effect of a potent cytochrome P450 (CYP) 3A inhibitor and CYP inducer on the pharmacokinetics of ritlecitinib, a JAK3/TEC family kinase inhibitor, and assess the effect of ritlecitinib on the pharmacokinetics of CYP substrates (midazolam, efavirenz, tolbutamide, caffeine and oral contraceptives [ethinyl oestradiol and levonorgestrel])
Vivek S. Purohit+6 more
wiley +1 more source
Demographic characteristics associated with a penicillin allergy label during pregnancy. [PDF]
Buckey TM+5 more
europepmc +1 more source
Aims Amgevita is a licensed biosimilar to adalimumab, having demonstrated high pharmacokinetic and clinical similarity to Humira. Switching to a lower‐cost medicine may elicit a nocebo effect, whereby expectations of poorer efficacy impact outcomes despite pharmacological similarity. This prospective cohort study examined clinical and economic outcomes
Louise Rabbitt+7 more
wiley +1 more source
Forensic Support for Abraham et al.'s BB Protocol. [PDF]
You Q+5 more
europepmc +1 more source
Listening to Hong Kong children's perspectives through pretend play
Abstract Quality in early childhood education and care (ECEC) has become an increasing concern in recent years. The issue has been regularly discussed by different stakeholders. However, the rising concern regarding quality in ECEC has not seriously taken into account children's perspectives.
Suzannie K. Y. Leung
wiley +1 more source
How accessible are the websites of health services for people who have had a stroke? [PDF]
Giummarra MJ+6 more
europepmc +1 more source
Reception Baseline Assessment and ‘small acts’ of micro‐resistance
Abstract In September 2021, following the global COVID‐19 pandemic, the Department for Education introduced a national standardised digital Reception Baseline Assessment (RBA) for all English 4‐year‐old children. We analyse RBA and its associated Quality Monitoring Visits, as a further intensification of the new public management of early years ...
Guy Roberts‐Holmes+2 more
wiley +1 more source
Comparative Evaluation of Fluoride Release/Uptake and Physical Properties of Self-adhesive GC Gold Label Hybrid and Antibiotic-modified Glass Ionomer Cement: An <i>In Vitro</i> Study. [PDF]
Done V+4 more
europepmc +1 more source
Abstract With levels of mental health difficulties among young people rising and policymakers focusing on the state's role in promoting young people's wellbeing, educational institutions have become positioned on the front line as key sites to identify and implement wellbeing interventions.
Ceri Brown+3 more
wiley +1 more source
Prescribing patterns of glucagon-like peptide-1 receptor agonists in the Swedish capital region-a register-based cross-sectional study. [PDF]
Fors A+3 more
europepmc +1 more source