Results 111 to 120 of about 170,345 (285)
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Canadian Journal of Applied Linguistics, 2015 Numerous studies, examining the acquisition of non-referential it in [-pro-drop] English by learners of [+pro-drop] languages, have revealed that their participants omit non-referential subjects in English if their L1 allows null-subject position ...
Elena Antonova-Ünlü
doaj
Experiencers at the syntax-pragmatics interface. The case of the jo ‘I’ – construction in Catalan
GlossaThis paper aims to support the thesis that Speech Act related operators have landing sites in syntax, specifically at the syntax-pragmatics interface. In order to attain this goal, it presents the first formal analysis of a construction, dubbed the jo ‘I’
M.Teresa Espinal, Sonia Cyrino
doaj +2 more sources
Register variation, truncation, and subject omission in English and in French [PDF]
, 2017 This paper concerns the null subject phenomenon attested in abbreviated written registers in English and in French (diaries, instructions) and in informal spoken English.
Haegeman, Liliane
core
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Revista do GEL, 2005 A lingua materna (LM) deixa marcas inevitáveis na interlíngua de aprendizes de uma lingua estrangeira (LE). 0 input recebido e a conscientização das diferenças entre as línguas são fundamentais no desenvolvimento da LE.
Ana Paula Marques Beato Canato +1 more
doaj
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Revista do GEL, 2014 A lingua materna (LM) deixa marcas inevitáveis na interlíngua de aprendizes de uma lingua estrangeira (LE). 0 input recebido e a conscientização das diferenças entre as línguas são fundamentais no desenvolvimento da LE.
Ana Paula Marques Beato Canato +1 more
doaj
In support of long distance agree [PDF]
, 2009 In the recent literature the phenomenon of long distance agreement has become the focus of several studies as it seems to violate certain locality conditions which require that agreeing elements in general stand in clause-mate relationships.
Alexiadou, Artemis +3 more
core
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source